特异性抗t淋巴细胞血清

Pierre Grabar, Felix Loisillier
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引用次数: 1

摘要

继续我们对胸腺细胞特异性抗原的研究,发现其中一种抗原在小脑中特别丰富,并开发了一种方法来分离它。从大鼠小脑中获得的免疫血清中对这种抗原的活性被类似的人或动物制剂完全吸收。因此,我们使用纯化的小牛小脑抗原对家兔进行免疫。这种方法的优点是它不需要吸收免疫血清,因为这种纯化的制剂不含有其他细胞常见的不需要的抗原。这些血清中的标记抗体可以检测到人类或动物的T淋巴细胞。然而,并不是所有注射的动物都产生了令人满意的免疫血清。讨论了抗原的免疫化学结构问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Specific anti-T lymphocyte serum

Continuing our research on specific thymocyte antigens, it was shown that one of these antigens is particularly abundant in the cerebellum and a method has been developed lor its isolation. The activity in immune sera against this antigen, obtained with rat cerebellum, was completely absorbed by analogous human or animal preparations. We therefore used the purified antigen from calf cerebellum to immunize rabbits. The advantage of this method is that it does not require absorption of the immune sera since this purified preparation does not contain undesired antigens common to other cells. Labelled antibodies from these sera allowed detection of human or animal T lymphocytes. However, not all injected animals produced satisfactory immune sera. The problem of the immunochemical structure of the antigen is discussed.

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