J Sverd, S S Kupietz, B G Winsberg, M J Hurwic, L Becker
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Effects of L-5-hydroxytryptophan in autistic children.
Behavioral effects of L-5-Hydroxytrophan (L-5-HTP), administered in combination with carbidopa, were evaluated in three autistic children using direct behavioral observation and parent ratings. Children were assessed under each of four experimental conditions: Baseline, Placebo I, L-5-HTP plus carbidopa, and Placebo II. During the 20-week study two children showed behavioral change that appeared to be unrelated to drug treatment. The findings did not support the hypothesis that a functional deficit in brain 5-HT underlies the autistic syndrome.
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