Rapid Evaluation of Anti-inflammatory Effect of Geniopicroside

: Skin acts as a barrier and is an important part of body immune system. External physical, biochemical and other stimuli might cause skin inflammation. Drugs and cosmetics have been developed for skin inflammation treatment. At present, the tests of skin inflammation are mainly conducted on animal and 2D cell models. The former might bring problems such as ethics and authenticity, while the latter cannot fully represent the complex micro-environment of the human body. Microfluidic based Organ-on- a-chips technology provides a new method for drug and cosmetic ingredient screening. Skin-on-a-chip (SOC) has been designed for constructing in vitro skin models. In this paper, a SOC was developed to culture skin-like models in vitro . We tested the differentiation of SOC cultured skin model