{"title":"一些融合三氮基苯并咪唑的合成及抗线虫活性研究","authors":"K. Anichina, Sofia Bulgaria Metallurgy","doi":"10.31435/RSGLOBAL_CONF/30122020/7351","DOIUrl":null,"url":null,"abstract":"4-Aryl-3,4-dihydro[1,3,5]triazino[1,2-a]benzimidazole-2-amines 3a-f were synthesized in the reaction of cyclocondensation between 2-guanidinobenzimidazole and versatilebenzaldehydes. Structures of all prepared compounds were confirmed by IR, 1H NMR spectroscopyand elemental analysis.Antinematodal activity in vitro of the substances was investigated using isolated Trichinella spiralis muscle larvae. The tested triazonobenzimidazoles showed different activity depending on the substituent R in their moleculeas the derivatives substituted with a hydroxyl group demonstrated the best anti-Trichinella spiralis activity in the series.","PeriodicalId":253725,"journal":{"name":"Proceedings of the XXIV International Scientific and Practical Conference","volume":"30 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"SYNTHESIS AND ANTINEMATODAL ACTIVITY STUDIES OF SOME FUSED TRIAZINOBENZIMIDAZOLES\",\"authors\":\"K. Anichina, Sofia Bulgaria Metallurgy\",\"doi\":\"10.31435/RSGLOBAL_CONF/30122020/7351\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"4-Aryl-3,4-dihydro[1,3,5]triazino[1,2-a]benzimidazole-2-amines 3a-f were synthesized in the reaction of cyclocondensation between 2-guanidinobenzimidazole and versatilebenzaldehydes. Structures of all prepared compounds were confirmed by IR, 1H NMR spectroscopyand elemental analysis.Antinematodal activity in vitro of the substances was investigated using isolated Trichinella spiralis muscle larvae. The tested triazonobenzimidazoles showed different activity depending on the substituent R in their moleculeas the derivatives substituted with a hydroxyl group demonstrated the best anti-Trichinella spiralis activity in the series.\",\"PeriodicalId\":253725,\"journal\":{\"name\":\"Proceedings of the XXIV International Scientific and Practical Conference\",\"volume\":\"30 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-12-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the XXIV International Scientific and Practical Conference\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31435/RSGLOBAL_CONF/30122020/7351\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the XXIV International Scientific and Practical Conference","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31435/RSGLOBAL_CONF/30122020/7351","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
SYNTHESIS AND ANTINEMATODAL ACTIVITY STUDIES OF SOME FUSED TRIAZINOBENZIMIDAZOLES
4-Aryl-3,4-dihydro[1,3,5]triazino[1,2-a]benzimidazole-2-amines 3a-f were synthesized in the reaction of cyclocondensation between 2-guanidinobenzimidazole and versatilebenzaldehydes. Structures of all prepared compounds were confirmed by IR, 1H NMR spectroscopyand elemental analysis.Antinematodal activity in vitro of the substances was investigated using isolated Trichinella spiralis muscle larvae. The tested triazonobenzimidazoles showed different activity depending on the substituent R in their moleculeas the derivatives substituted with a hydroxyl group demonstrated the best anti-Trichinella spiralis activity in the series.
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