低成本啮齿动物活动监测仪器

M. Bergen, S.A. Soldan, S. Reisman, J. Ottenweller
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摘要

慢性疲劳综合症(CFS)是一种导致中度至重度残疾的疾病。慢性疲劳综合症的一个主要症状是,患者报告说,由于疲劳相关症状,他们的体力活动水平急剧下降。我们开发了一种啮齿类动物模型,使用大鼠、仓鼠和小鼠,使我们能够在一个综合框架中研究疲劳和生理节律。动物的活动是研究这些节律和慢性疲劳的一个非常重要的指标。为了监测自由放养的啮齿动物的活动,我们使用了两种互补的方法:第一种是红外光束,用于检测和计数运行轮的转动,第二种是位于房屋桶下的力传感器,用于检测一般运动。这两种方法都是在动物的家庭笼子中使用的,与商业单位相比,成本较低,适用于许多动物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Low cost rodent activity monitoring instrumentation
Chronic fatigue syndrome (CFS) is a condition that results in moderate to severe disability. A leading symptom of CFS is that patients report critical reductions in their levels of physical activity due to fatigue related symptoms. We have developed a rodent model, using rats, hamsters, and mice, that enables us to investigate fatigue and physiological rhythms in an integrated framework. The animal's activity is one measure of great importance in the study of these rhythms and chronic fatigue. To monitor a free-ranging rodent's activity we utilize two complementing methods: first, is an infra-red photo beam to detect and count turns of a running wheel, and second, is a force sensor located under the housing tub to detect general motion. Both methods are used in the animal's home cage and are made to be low cost, compared to commercial units, for implementation on many animals.
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