M. Saravani, Mohsen Rokni, M. Mehrbani, Arian Amirkhosravi, Sanaz Faramarz, I. Fatemi, Mojdeh Esmaeili Tarzi, M. Nematollahi
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The evaluation of VEGF and HIF‐1α gene polymorphisms and multiple sclerosis susceptibility
Multiple sclerosis (MS) is an autoimmune disease that leads to myelin sheath destruction. Hypoxia‐inducible factor 1 (HIF‐1) has several roles in cells, such as inducing inflammation and angiogenesis. Recently, several lines of evidence have indicated the role of the hypoxia response and the HIF‐1 signaling pathway in an autoimmune disease such as MS. The present study aimed to evaluate the effects of HIF‐1α gene polymorphisms and vascular endothelial growth factor (VEGF) (as a major target gene of HIF‐1α) gene polymorphism on MS susceptibility.
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