基于含4-亚硝基三氟甲基的生物活性化合物的合成

VIII Information school of a young scientist Central Scientific Library of the Urals Branch of the Russian Academy of Science Pub Date : 2020-12-16 DOI:10.32460/ISHMU-2020-8-0009

N. Agafonova, E. Shchegolkov, Y. Burgart, V. I. Saloutin, M. Ulitko

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摘要

1,3-二酮或其锂盐的电子锅亚硝化，然后处理肼。亚硝基衍生物的还原可以得到4-氨基-3-三氟甲基吡唑氯化物。体外评价了化合物的细胞毒活性

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Synthesis of biological active compounds based on trifluoromethylcontaining 4-nitrosopyrazoles

e-pot nitrosation of 1,3-diketones or their lithium salts followed by treatment of hydrazines. Reduction of the nitroso-derivatives made it possible to obtain the 4-amino-3-trifluoromethylpyrazoles chlorides. Cytotoxic activity of the compounds wase evaluated in vitro

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VIII Information school of a young scientist Central Scientific Library of the Urals Branch of the Russian Academy of Science

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