A. Olamide, A. Kayode, A. David, O. Idowu, U. O. Christina, O. Victor, A. A. Rotimi
{"title":"藤黄果种子乙醇提取物对成年Wistar大鼠睾丸和附睾的显微形态和体视学影响","authors":"A. Olamide, A. Kayode, A. David, O. Idowu, U. O. Christina, O. Victor, A. A. Rotimi","doi":"10.5580/833","DOIUrl":null,"url":null,"abstract":"The objective of this study was to evaluate testicular and epididymal alterations resulting from the administration of ethanolic extract of Garcinia cambogia by morphometric methods. Fifteen (15) rats weighing between 120-135g were used for the study. These were divided into control and experimental groups of 5 rats each. They were given ethanolic extract at doses of 0.00mg/kg B.W (control), 100mg/kg B.W (Group B), 200mg/kg B.W (Group C) respectively by gastric lavage for 6 weeks. Five slides chosen at random from the testicular slides of control and experimental were evaluated and analyzed. There was a reduction in the germinative cell thickness of the seminiferous tubules in the treated group compare with control. There was a significant increase in the sperm counts but reduction in motility in the treated groups in a dose dependent manner compare with control (P<0.05). The volume density ratio of lumen was increased in the treated groups which receive the higher dose of extract compared with the control.","PeriodicalId":107168,"journal":{"name":"The Internet Journal of Alternative Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2006-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"39","resultStr":"{\"title\":\"Micromorphometric and Stereological Effects of Ethanolic Extracts of Garcinia cambogia seeds on the Testes and Epididymides of Adult Wistar Rats\",\"authors\":\"A. Olamide, A. Kayode, A. David, O. Idowu, U. O. Christina, O. Victor, A. A. Rotimi\",\"doi\":\"10.5580/833\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The objective of this study was to evaluate testicular and epididymal alterations resulting from the administration of ethanolic extract of Garcinia cambogia by morphometric methods. Fifteen (15) rats weighing between 120-135g were used for the study. These were divided into control and experimental groups of 5 rats each. They were given ethanolic extract at doses of 0.00mg/kg B.W (control), 100mg/kg B.W (Group B), 200mg/kg B.W (Group C) respectively by gastric lavage for 6 weeks. Five slides chosen at random from the testicular slides of control and experimental were evaluated and analyzed. There was a reduction in the germinative cell thickness of the seminiferous tubules in the treated group compare with control. There was a significant increase in the sperm counts but reduction in motility in the treated groups in a dose dependent manner compare with control (P<0.05). The volume density ratio of lumen was increased in the treated groups which receive the higher dose of extract compared with the control.\",\"PeriodicalId\":107168,\"journal\":{\"name\":\"The Internet Journal of Alternative Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2006-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"39\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Internet Journal of Alternative Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5580/833\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Internet Journal of Alternative Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5580/833","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Micromorphometric and Stereological Effects of Ethanolic Extracts of Garcinia cambogia seeds on the Testes and Epididymides of Adult Wistar Rats
The objective of this study was to evaluate testicular and epididymal alterations resulting from the administration of ethanolic extract of Garcinia cambogia by morphometric methods. Fifteen (15) rats weighing between 120-135g were used for the study. These were divided into control and experimental groups of 5 rats each. They were given ethanolic extract at doses of 0.00mg/kg B.W (control), 100mg/kg B.W (Group B), 200mg/kg B.W (Group C) respectively by gastric lavage for 6 weeks. Five slides chosen at random from the testicular slides of control and experimental were evaluated and analyzed. There was a reduction in the germinative cell thickness of the seminiferous tubules in the treated group compare with control. There was a significant increase in the sperm counts but reduction in motility in the treated groups in a dose dependent manner compare with control (P<0.05). The volume density ratio of lumen was increased in the treated groups which receive the higher dose of extract compared with the control.