[δ -8- thc与人血清蛋白的结合:结合与脂蛋白组成的关系]。

European journal of toxicology and environmental hygiene. Journal europeen de toxicologie Pub Date : 1976-01-01

N Capelle, I Treich, M Ayrault-Jarrier, H Hoellinger, J M Scherrmann

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引用次数: 0

摘要

根据人体脂蛋白组成的功能，利用不同脂质谱的血清，通过超离心和分离分离，研究了delta9THC的异构体delta8tetrahydrocannabinol的分布，并对VLDL、LDL和HDL组分以及非脂蛋白蛋白组分进行了生化分析。结果表明，δ - 8 - thc的分布与脂蛋白cenapse的磷脂之间存在线性相关。结合δ - 8 - thc的数量与其他脂蛋白成分胆固醇、甘油三酯、总脂质或蛋白质没有相关性。

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[Binding of delta-8-THC to human serum proteins: binding as a function of lipoprotein composition].

In accordance with the function of the human lipoprotein composition, using serum of different lipid profiles, the distribution of delta8tetrahydrocannabinol, as isomer of delta9THC, was studied through the use of ultracentrifugation and fraction isolation, followed by biochemical analysis of the VLDL, LDL, and HDL fractions, as well as that of the non-lipoprotein protein fraction. The results indicate the existence of a linear correlation between the distribution of delta8THC and the phospholipids of the lipoprotein cenapse. No correlation between the quantity of bound delta8THC and the other lipoprotein constituents cholesterol, triglycerides, total lipids or protein could be observed.

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European journal of toxicology and environmental hygiene. Journal europeen de toxicologie

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