海芋属生物碱。第二十二。红花中具有降血压和抗菌活性生物碱的分离。

Lloydia Pub Date : 1977-09-01

W N Wu, J L Beal, R W Doskotch

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引用次数: 0

摘要

从大头菜中分离鉴定了16种生物碱。,即;thalidasine, O-methylthalmethine, O-methylthalicberine, thalrugosaminine, thalicarpine, thalmelatine, pennsylvanine, palmatine, berberine, thalifendine, columbamine, jatrorhizine, deoxythalidastine, thalphenine和magnoflorine。先前在部分数据上提出的双苄基异喹啉型thairugosaminine(1)的结构完全建立，包括S,S的绝对构型。Thalphenine、thalidasine、O-methylthalicberine、thalicarpine、thalrugosaminine和thaliglucinone在家兔中具有降压活性。Thalrugosaminine、thalicarpine、thalmelatine、O-methylthalmethine、pennsylvanine和thalphenine对耻垢分枝杆菌有活性。

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Alkaloids of Thalictrum. XXII. Isolation of alkaloids with hypotensive and antimicrobial activity from Thalictrum revolutum.

Sixteen alkaloids were characterized from Thalictrum revolutum DC., namely; thalidasine, O-methylthalmethine, O-methylthalicberine, thalrugosaminine, thalicarpine, thalmelatine, pennsylvanine, palmatine, berberine, thalifendine, columbamine, jatrorrhizine, deoxythalidastine, thalphenine and magnoflorine. The structure of thairugosaminine (1) a bisbenzylisoquinoline type which was previously proposed on partial data was completely established, including the absolute configuration as S,S. Thalphenine, thalidasine, O-methylthalicberine, thalicarpine, thalrugosaminine and thaliglucinone were found to possess hypotensive activity in rabbits. Thalrugosaminine, thalicarpine, thalmelatine, O-methylthalmethine, pennsylvanine and thalphenine were found to be active against Mycobacterium smegmatis.

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Lloydia

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