{"title":"幼鼠肝实质细胞增殖的脉冲模式。肝细胞dna合成的自然同步。","authors":"N A Miljutina, E M Kogan, M A Nekhljudova","doi":"10.1007/BF02899351","DOIUrl":null,"url":null,"abstract":"<p><p>The present investigation is concerned with natural synchronization of DNA-synthesizing hepatocytes in the growing liver of young mice. It has been found that in individual specimens, 30--40% of all the parenchymal liver cells pass through the S phase within about 22 h. These cells are grouped into two large synchronous fractions, so-called \"S-pulses\". The time interval between the formation of these \"S-pulses\" is assigned by the duration of the S phase. It is shown that the maximum separate \"S-pulse\" involves 20% of the total hepatocyte population.</p>","PeriodicalId":76800,"journal":{"name":"Virchows Archiv. B, Cell pathology","volume":"29 3","pages":"179-90"},"PeriodicalIF":0.0000,"publicationDate":"1978-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02899351","citationCount":"0","resultStr":"{\"title\":\"Pulsed pattern of proliferation in liver parenchyma of young mice. Natural synchronization of DNA-synthesizing hepatocytes.\",\"authors\":\"N A Miljutina, E M Kogan, M A Nekhljudova\",\"doi\":\"10.1007/BF02899351\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The present investigation is concerned with natural synchronization of DNA-synthesizing hepatocytes in the growing liver of young mice. It has been found that in individual specimens, 30--40% of all the parenchymal liver cells pass through the S phase within about 22 h. These cells are grouped into two large synchronous fractions, so-called \\\"S-pulses\\\". The time interval between the formation of these \\\"S-pulses\\\" is assigned by the duration of the S phase. It is shown that the maximum separate \\\"S-pulse\\\" involves 20% of the total hepatocyte population.</p>\",\"PeriodicalId\":76800,\"journal\":{\"name\":\"Virchows Archiv. B, Cell pathology\",\"volume\":\"29 3\",\"pages\":\"179-90\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1978-12-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/BF02899351\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Virchows Archiv. B, Cell pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/BF02899351\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Virchows Archiv. B, Cell pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF02899351","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Pulsed pattern of proliferation in liver parenchyma of young mice. Natural synchronization of DNA-synthesizing hepatocytes.
The present investigation is concerned with natural synchronization of DNA-synthesizing hepatocytes in the growing liver of young mice. It has been found that in individual specimens, 30--40% of all the parenchymal liver cells pass through the S phase within about 22 h. These cells are grouped into two large synchronous fractions, so-called "S-pulses". The time interval between the formation of these "S-pulses" is assigned by the duration of the S phase. It is shown that the maximum separate "S-pulse" involves 20% of the total hepatocyte population.
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