五胃泌素对大鼠胃粘膜组胺释放的影响。

Acta hepato-gastroenterologica Pub Date : 1979-04-01

N Subramanian, P Mitznegg, W Domschke, S Domschke, C Faschingbauer

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摘要

用超融合模型研究了大鼠离体胃黏膜组胺的释放。Pentagastrin以剂量依赖的方式增加组胺的基础外排。在类似条件下，分泌素对组胺的释放没有影响。这一结果与胃粘膜五味素释放组胺的观点相一致，组胺随后可能与壁细胞受体反应，从而在酸分泌过程中起中介作用。

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Histamine-release in rat gastric mucosa by pentagastrin.

The release of histamine from isolated gastric mucosa of the rat was studied by a superfusion model. Pentagastrin increased the basal efflux of histamine in a dose dependent manner. Secretin failed to influence the release of histamine under similar conditions. The results are compatible with the view that in gastric mucosa pentagastrin releases histamine which then may react with the receptors of the parietal cell thus serving as mediator in the acid secretory process.

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Acta hepato-gastroenterologica

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