{"title":"人体分泌成分- i。新的抗原特异性证据","authors":"S. Iscaki , Colette Geneste , J. Pillot","doi":"10.1016/0161-5890(78)90138-4","DOIUrl":null,"url":null,"abstract":"<div><p>In the present work, we have studied the antigenically reactive regions of S.C. with immune sera of well-defined specificity. Immunochemical analyses conducted with an I.S. containing only precipitating antibodies against a hidden S.C. group of determinants, unravels the existence of a new antigenic specificity that we chose to call provisionally “R” (from mercapto-resistant). R was shown to be completely independent from Brandtzaeg's I and A<sub>1</sub> by its resistance to strong reduction and to be distinct from A<sub>2</sub> by the fact that anti-R antibodies do not precipitate sIgA or tryptic S.C.</p><p>The experiments described show that R occurs unaltered on spontaneously degraded S.C. as well as on the 35.000 daltons fragment from peptic digestion.</p><p>By crossed passive hemagglutination inhibition two distinct parts of the R specificity were found to occur on sIgA and tryptic S.C. respectively.</p><p>The R specificity could be located on the S.C. near the site(s) where this molecule is fixed on IgA.</p></div>","PeriodicalId":13265,"journal":{"name":"Immunochemistry","volume":"15 6","pages":"Pages 401-408"},"PeriodicalIF":0.0000,"publicationDate":"1978-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0161-5890(78)90138-4","citationCount":"24","resultStr":"{\"title\":\"Human secretory component—I. Evidence for a new antigenic specificity\",\"authors\":\"S. Iscaki , Colette Geneste , J. Pillot\",\"doi\":\"10.1016/0161-5890(78)90138-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In the present work, we have studied the antigenically reactive regions of S.C. with immune sera of well-defined specificity. Immunochemical analyses conducted with an I.S. containing only precipitating antibodies against a hidden S.C. group of determinants, unravels the existence of a new antigenic specificity that we chose to call provisionally “R” (from mercapto-resistant). R was shown to be completely independent from Brandtzaeg's I and A<sub>1</sub> by its resistance to strong reduction and to be distinct from A<sub>2</sub> by the fact that anti-R antibodies do not precipitate sIgA or tryptic S.C.</p><p>The experiments described show that R occurs unaltered on spontaneously degraded S.C. as well as on the 35.000 daltons fragment from peptic digestion.</p><p>By crossed passive hemagglutination inhibition two distinct parts of the R specificity were found to occur on sIgA and tryptic S.C. respectively.</p><p>The R specificity could be located on the S.C. near the site(s) where this molecule is fixed on IgA.</p></div>\",\"PeriodicalId\":13265,\"journal\":{\"name\":\"Immunochemistry\",\"volume\":\"15 6\",\"pages\":\"Pages 401-408\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1978-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0161-5890(78)90138-4\",\"citationCount\":\"24\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Immunochemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0161589078901384\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunochemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0161589078901384","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Human secretory component—I. Evidence for a new antigenic specificity
In the present work, we have studied the antigenically reactive regions of S.C. with immune sera of well-defined specificity. Immunochemical analyses conducted with an I.S. containing only precipitating antibodies against a hidden S.C. group of determinants, unravels the existence of a new antigenic specificity that we chose to call provisionally “R” (from mercapto-resistant). R was shown to be completely independent from Brandtzaeg's I and A1 by its resistance to strong reduction and to be distinct from A2 by the fact that anti-R antibodies do not precipitate sIgA or tryptic S.C.
The experiments described show that R occurs unaltered on spontaneously degraded S.C. as well as on the 35.000 daltons fragment from peptic digestion.
By crossed passive hemagglutination inhibition two distinct parts of the R specificity were found to occur on sIgA and tryptic S.C. respectively.
The R specificity could be located on the S.C. near the site(s) where this molecule is fixed on IgA.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
