Nonenzymatic hydrolysis reactions of adenosine 5′-triphosphate and its related compounds—III: Catalytic aspects of some cobalt(III) complexes in ATP-hydrolysis

Trichlorodiethylenetriaminecobalt(III), [CoCl₃dien], which is provided with three good leaving ligands and, hence, capable of binding ATP in a characteristic mode, accelerated effectively and specifically hydrolysis of ATP to ADP and Pi. A kinetic study of the reaction indicated that the rate of hydrolysis was first order with respect to the concentration of ATP in the presence of an excess of [CoCl₃dien]. The rate constant was calculated to be 1.05 × 10⁻² min⁻¹ at pH 4.0 (50°C), corresponding to a catalysis of the hydrolysis of ATP by a factor of 150. The complex possessing one good