约翰·斯奎尔和内皮糖盏结构：一个未完成的故事。

IF 1.8 3区生物学 Q4 CELL BIOLOGY

Journal of Muscle Research and Cell Motility Pub Date : 2023-09-01 Epub Date: 2022-10-19 DOI:10.1007/s10974-022-09629-x

Kenton P Arkill, C Charles Michel, Elizabeth V M Rider, Elise A Wood, Mathew O Small, Jennifer L E Brown, Abigail L Kinnaird

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引用次数: 3

摘要

约翰·斯奎尔不仅在肌肉领域取得了领先的成果，他还通过内皮糖盏的超微结构分析对血管通透性领域做出了重大贡献。以下是他的主要合作者C.C.米歇尔和他的最后一位博士后研究员KP Arkill对他参与该领域的回顾。最后，我们对他的工作进行了重新解释，可以说，这与我们目前对内皮糖盏结构和组成的理解有关，即每个syndecan核心蛋白预测6个糖胺聚糖纤维，仅在内皮中通过二聚化实现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

John squire and endothelial glycocalyx structure: an unfinished story.

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John squire and endothelial glycocalyx structure: an unfinished story.

John Squire did not only produce leading works in the muscle field, he also significantly contributed to the vascular permeability field by ultrastructural analysis of the endothelial glycocalyx. Presented here is a review of his involvement in the field by his main collaborator C.C. Michel and his last postdoctoral researcher KP Arkill. We end on a reinterpretation of his work that arguably links to our current understanding of endothelial glycocalyx structure and composition predicting 6 glycosaminoglycans fibres per syndecan core protein, only achieved in the endothelium by dimerization.

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来源期刊

Journal of Muscle Research and Cell Motility 生物-细胞生物学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Muscle Research and Cell Motility has as its main aim the publication of original research which bears on either the excitation and contraction of muscle, the analysis of any one of the processes involved therein, the processes underlying contractility and motility of animal and plant cells, the toxicology and pharmacology related to contractility, or the formation, dynamics and turnover of contractile structures in muscle and non-muscle cells. Studies describing the impact of pathogenic mutations in genes encoding components of contractile structures in humans or animals are welcome, provided they offer mechanistic insight into the disease process or the underlying gene function. The policy of the Journal is to encourage any form of novel practical study whatever its specialist interest, as long as it falls within this broad field. Theoretical essays are welcome provided that they are concise and suggest practical ways in which they may be tested. Manuscripts reporting new mutations in known disease genes without validation and mechanistic insight will not be considered. It is the policy of the journal that cells lines, hybridomas and DNA clones should be made available by the developers to any qualified investigator. Submission of a manuscript for publication constitutes an agreement of the authors to abide by this principle.