TRPV4通道在皮肤上皮细胞中的作用。

4区生物学 Q4 Biochemistry, Genetics and Molecular Biology

Current topics in membranes Pub Date : 2022-01-01 Epub Date: 2022-08-01 DOI:10.1016/bs.ctm.2022.06.003

Carlene Moore

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引用次数: 0

摘要

瞬时受体电位香草素4（TRPV4）通道是多模式激活的阳离子可渗透通道，其在包括皮肤在内的大多数器官组织中表达。TRPV4在皮肤中高度表达，并在皮肤驻留细胞如表皮角质形成细胞、黑素细胞、免疫肥大细胞和巨噬细胞以及皮肤神经元中发挥作用。TRPV4在皮肤稳态中发挥许多关键作用，影响广泛的过程，如温度感、渗透压感、毛发生长、细胞凋亡、皮肤屏障完整性、分化、伤害性和瘙痒。由于TRPV4在多种病理状态下发挥作用，TRPV4可以成为慢性疼痛、瘙痒和皮肤癌症等疾病的多功能治疗靶点。

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The role of TRPV4 channels in cutaneous epithelia.

Transient receptor potential vanilloid 4 (TRPV4) channels are multi-modally activated cation permeable channels that are expressed most organ tissues including the skin. TRPV4 is highly expressed in the skin and functions in skin resident cells such as epidermal keratinocytes, melanocytes, immune mast cells and macrophages, and cutaneous neurons. TRPV4 plays many crucial roles in skin homeostasis to affect an extensive range of processes such as temperature sensation, osmo-sensation, hair growth, cell apoptosis, skin barrier integrity, differentiation, nociception and itch. Since TRPV4 functions in a plenitude of pathological states, TRPV4 can become a versatile therapeutic target for diseases such as chronic pain, itch and skin cancer.

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来源期刊

Current topics in membranes 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.