日本2011 - 2014年出生的248例唇腭裂患儿相关先天性异常及综合征的环境与儿童研究

IF 1.3 4区 医学 Q3 PEDIATRICS
Yukihiro Sato, Eiji Yoshioka, Yasuaki Saijo, Yasuhito Kato, Ken Nagaya, Satoru Takahashi, Yoshiya Ito, Sumitaka Kobayashi, Yu Ait Bamai, Keiko Yamazaki, Sachiko Itoh, Chihiro Miyashita, Atsuko Ikeda-Araki, Reiko Kishi, The Japan Environment and Children's Study (JECS) Group
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引用次数: 2

摘要

本研究旨在记录日本2011 - 2014年出生的唇腭裂婴儿的并发症情况。这是一项描述性研究,使用的数据来自日本环境与儿童研究。在103 060例妊娠中,包括248例唇腭裂婴儿(活产239例;死胎,4;感兴趣的项目是口面裂的并发症状况:孤立的(只有典型的口面裂);多重畸形(不相关的重大缺陷的口面裂隙);综合征性的(伴有综合征或染色体缺陷的口面部裂)。248例唇腭裂患儿中,唇裂合并腭裂104例(41.9%),无腭裂合并唇裂68例(27.4%),无唇裂合并唇裂58例(23.4%),未分型18例(7.3%)。在CLP患儿中,孤立型、多畸形型和综合征型的比例分别为73.1%、15.4%和11.5%。在患有CL的婴儿中,这一比例分别为79.4%、16.2%和4.4%。在患有CP的婴儿中,这一比例分别为69.0%、13.8%和17.2%。最常见的相关先天性异常是先天性心脏病。在综合征型CLP婴儿中,41.7%患有13三体。在综合征型CP患儿中,80.0%具有Pierre Robin序列。先天性心脏病可能是最常见的先天性异常。最常见的相关综合征可能是CLP患者的13三体和CP患者的Pierre Robin序列。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associated congenital anomalies and syndromes of 248 infants with orofacial clefts born between 2011 and 2014 in the Japan environment and children's study

This study aimed to document the complication status of infants with orofacial clefts born between 2011 and 2014 in Japan. This was a descriptive study using data from the Japan Environment and Children's Study. Among 103 060 pregnancies, 248 infants with orofacial clefts were included (livebirth, 239; stillbirth, 4; miscarriage, 5). The items of interest were complication status of orofacial clefts: isolated (typical orofacial clefts only); multi-malformed (orofacial clefts with unrelated major defects); syndromic (orofacial clefts with a syndrome or a chromosomal defect). Regarding the cleft subtypes, of 248 infants with orofacial clefts, 104 had cleft lip with cleft palate (CLP) (41.9%), 68 had cleft lip without cleft palate (CL) (27.4%), 58 had cleft palate without cleft lip (CP) (23.4%), and 18 were nonclassified (7.3%). In infants with CLP, the proportions of isolated, multi-malformed, and syndromic phenotypes were 73.1%, 15.4%, and 11.5%, respectively. In infants with CL, the proportions were 79.4%, 16.2%, and 4.4%, respectively. In infants with CP, the proportions were 69.0%, 13.8%, and 17.2%, respectively. The most frequently associated congenital anomaly was congenital heart disease. In infants with syndromic CLP, 41.7% had trisomy 13. In infants with syndromic CP, 80.0% had the Pierre Robin sequence. Congenital heart disease could be the most frequently associated congenital anomaly. The most frequently associated syndrome could be trisomy 13 in those with CLP and Pierre Robin sequence in those with CP.

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来源期刊
Congenital Anomalies
Congenital Anomalies PEDIATRICS-
自引率
0.00%
发文量
49
审稿时长
>12 weeks
期刊介绍: Congenital Anomalies is the official English language journal of the Japanese Teratology Society, and publishes original articles in laboratory as well as clinical research in all areas of abnormal development and related fields, from all over the world. Although contributions by members of the teratology societies affiliated with The International Federation of Teratology Societies are given priority, contributions from non-members are welcomed.
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