PiB-PET显像显示完全缓解后心脏AL淀粉样蛋白沉积减少。

IF 5.2 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Amyloid-Journal of Protein Folding Disorders Pub Date : 2023-03-01 DOI:10.1080/13506129.2022.2120388

Kazuhiro Oguchi, Nagaaki Katoh, Yusuke Mochizuki, Yusuke Takahashi, Akihiro Ueno, Ken Takasone, Yoshiki Sekijima

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Reduction of cardiac AL amyloid deposition after complete response visualised by PiB-PET imaging.

C-Labeled Pittsburgh compound B (PiB) positron emission tomography (PET) was initially developed to evaluate Alzheimer’s disease. There has been recent progress in research on cardiac amyloidosis using PiB [1] and other amyloid PET diagnostic agents [2]. Previous studies reported that amyloid tracer uptake differed according to amyloidosis subtype [2,3], and in immunoglobulin light chain (AL) amyloidosis, the degree of cardiac PiB uptake was correlated with both the histological amyloid burden in the myocardium and unfavourable disease prognosis [4]. Although a small number of AL amyloidosis patients who underwent repeated amyloid PET before and after treatment have been reported, significant reduction of cardiac tracer uptake has not yet been demonstrated [5].

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来源期刊

Amyloid-Journal of Protein Folding Disorders 生物-生化与分子生物学

CiteScore

10.60

自引率

10.90%

发文量

审稿时长

6-12 weeks

期刊介绍： Amyloid: the Journal of Protein Folding Disorders is dedicated to the study of all aspects of the protein groups and associated disorders that are classified as the amyloidoses as well as other disorders associated with abnormal protein folding. The journals major focus points are: etiology, pathogenesis, histopathology, chemical structure, nature of fibrillogenesis; whilst also publishing papers on the basic and chemical genetic aspects of many of these disorders. Amyloid is recognised as one of the leading publications on amyloid protein classifications and the associated disorders, as well as clinical studies on all aspects of amyloid related neurodegenerative diseases and major clinical studies on inherited amyloidosis, especially those related to transthyretin. The Journal also publishes book reviews, meeting reports, editorials, thesis abstracts, review articles and symposia in the various areas listed above.