Petra J. W. Pouwels, Chris Vriend, Feng Liu, Niels T. de Joode, Maria C. G. Otaduy, Bruno Pastorello, Frances C. Robertson, Ganesan Venkatasubramanian, Jonathan Ipser, Seonjoo Lee, Marcelo C. Batistuzzo, Marcelo Q. Hoexter, Christine Lochner, Euripedes C. Miguel, Janardhanan C. Narayanaswamy, Rashmi Rao, Y. C. Janardhan Reddy, Roseli G. Shavitt, Karthik Sheshachala, Dan J. Stein, Anton J. L. M. van Balkom, Melanie Wall, Helen Blair Simpson, Odile A. van den Heuvel
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M. van Balkom, Melanie Wall, Helen Blair Simpson, Odile A. van den Heuvel","doi":"10.1002/mpr.1931","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objectives</h3>\n \n <p>We describe the harmonized MRI acquisition and quality assessment of an ongoing global OCD study, with the aim to translate representative, well-powered neuroimaging findings in neuropsychiatric research to worldwide populations.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We report on T1-weighted structural MRI, resting-state functional MRI, and multi-shell diffusion-weighted imaging of 140 healthy participants (28 per site), two traveling controls, and regular phantom scans.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Human image quality measures (IQMs) and outcome measures showed smaller within-site variation than between-site variation. Outcome measures were less variable than IQMs, especially for the traveling controls. Phantom IQMs were stable regarding geometry, SNR, and mean diffusivity, while fMRI fluctuation was more variable between sites.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Variation in IQMs persists, even for an a priori harmonized data acquisition protocol, but after pre-processing they have less of an impact on the outcome measures. Continuous monitoring IQMs per site is valuable to detect potential artifacts and outliers. The inclusion of both cases and healthy participants at each site remains mandatory.</p>\n </section>\n </div>","PeriodicalId":50310,"journal":{"name":"International Journal of Methods in Psychiatric Research","volume":"32 1","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ca/aa/MPR-32-e1931.PMC9976605.pdf","citationCount":"0","resultStr":"{\"title\":\"Global multi-center and multi-modal magnetic resonance imaging study of obsessive-compulsive disorder: Harmonization and monitoring of protocols in healthy volunteers and phantoms\",\"authors\":\"Petra J. W. Pouwels, Chris Vriend, Feng Liu, Niels T. de Joode, Maria C. G. Otaduy, Bruno Pastorello, Frances C. Robertson, Ganesan Venkatasubramanian, Jonathan Ipser, Seonjoo Lee, Marcelo C. Batistuzzo, Marcelo Q. Hoexter, Christine Lochner, Euripedes C. Miguel, Janardhanan C. 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Global multi-center and multi-modal magnetic resonance imaging study of obsessive-compulsive disorder: Harmonization and monitoring of protocols in healthy volunteers and phantoms
Objectives
We describe the harmonized MRI acquisition and quality assessment of an ongoing global OCD study, with the aim to translate representative, well-powered neuroimaging findings in neuropsychiatric research to worldwide populations.
Methods
We report on T1-weighted structural MRI, resting-state functional MRI, and multi-shell diffusion-weighted imaging of 140 healthy participants (28 per site), two traveling controls, and regular phantom scans.
Results
Human image quality measures (IQMs) and outcome measures showed smaller within-site variation than between-site variation. Outcome measures were less variable than IQMs, especially for the traveling controls. Phantom IQMs were stable regarding geometry, SNR, and mean diffusivity, while fMRI fluctuation was more variable between sites.
Conclusions
Variation in IQMs persists, even for an a priori harmonized data acquisition protocol, but after pre-processing they have less of an impact on the outcome measures. Continuous monitoring IQMs per site is valuable to detect potential artifacts and outliers. The inclusion of both cases and healthy participants at each site remains mandatory.
期刊介绍：
The International Journal of Methods in Psychiatric Research (MPR) publishes high-standard original research of a technical, methodological, experimental and clinical nature, contributing to the theory, methodology, practice and evaluation of mental and behavioural disorders. The journal targets in particular detailed methodological and design papers from major national and international multicentre studies. There is a close working relationship with the US National Institute of Mental Health, the World Health Organisation (WHO) Diagnostic Instruments Committees, as well as several other European and international organisations.
MPR aims to publish rapidly articles of highest methodological quality in such areas as epidemiology, biostatistics, generics, psychopharmacology, psychology and the neurosciences. Articles informing about innovative and critical methodological, statistical and clinical issues, including nosology, can be submitted as regular papers and brief reports. Reviews are only occasionally accepted.
MPR seeks to monitor, discuss, influence and improve the standards of mental health and behavioral neuroscience research by providing a platform for rapid publication of outstanding contributions. As a quarterly journal MPR is a major source of information and ideas and is an important medium for students, clinicians and researchers in psychiatry, clinical psychology, epidemiology and the allied disciplines in the mental health field.
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