{"title":"耐碳青霉烯肠杆菌科细菌的药敏模式。","authors":"Shahnaz Armin, Fatemeh Fallah, Abdollah Karimi, Fereshteh Karbasiyan, Masoud Alebouyeh, Sedigheh Rafiei Tabatabaei, Maryam Rajabnejad, Roxana Mansour Ghanaie, Seyed Alireza Fahimzad, Nafiseh Abdollahi, Hannan Khodaei, Leila Azimi","doi":"10.1155/2023/8920977","DOIUrl":null,"url":null,"abstract":"<p><p>Carbapenem is a broad-spectrum beta-lactam antibiotic considered the last choice for the treatment of antibiotic-resistant Gram-negative bacteria. Thus, the increasing rate of carbapenem resistance (CR) in Enterobacteriaceae is an urgent public health threat. This study aimed to evaluate the antibiotic susceptibility pattern of carbapenem-resistant <i>Enterobacteriaceae</i> (CRE) to new and old antibiotics. In this study, <i>Klebsiella pneumoniae</i>, <i>E. coli</i>, and <i>Enterobacter</i> spp. were collected from 10 hospitals in Iran for one year. CRE is recognized by resistance to meropenem and/or imipenem disk after identification of the collected bacteria. Antibiotic susceptibility of CRE against fosfomycin, rifampin, metronidazole, tigecycline, and aztreonam was detected by disk diffusion method and colistin by MIC. In this study, 1222 <i>E. coli</i>, 696 <i>K. pneumoniae</i>, and 621 <i>Enterobacter</i> spp. were collected from 10 hospitals in Iran in one year. Fifty-four <i>E. coli</i> (4.4%), 84 <i>K. pneumoniae</i> (12%), and 51 <i>Enterobacter</i> spp. (8.2%) were CRE. All CRE strains were resistant to metronidazole and rifampicin. Tigecycline has the highest sensitivity on CRE and levofloxacin for <i>Enterobacter</i> spp. Tigecycline showed an acceptable effectiveness rate of sensitivity on the CRE strain. Therefore, we suggest that clinicians consider this valuable antibiotic to treat CRE.</p>","PeriodicalId":14098,"journal":{"name":"International Journal of Microbiology","volume":"2023 ","pages":"8920977"},"PeriodicalIF":2.8000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970715/pdf/","citationCount":"3","resultStr":"{\"title\":\"Antibiotic Susceptibility Patterns for Carbapenem-Resistant Enterobacteriaceae.\",\"authors\":\"Shahnaz Armin, Fatemeh Fallah, Abdollah Karimi, Fereshteh Karbasiyan, Masoud Alebouyeh, Sedigheh Rafiei Tabatabaei, Maryam Rajabnejad, Roxana Mansour Ghanaie, Seyed Alireza Fahimzad, Nafiseh Abdollahi, Hannan Khodaei, Leila Azimi\",\"doi\":\"10.1155/2023/8920977\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Carbapenem is a broad-spectrum beta-lactam antibiotic considered the last choice for the treatment of antibiotic-resistant Gram-negative bacteria. Thus, the increasing rate of carbapenem resistance (CR) in Enterobacteriaceae is an urgent public health threat. This study aimed to evaluate the antibiotic susceptibility pattern of carbapenem-resistant <i>Enterobacteriaceae</i> (CRE) to new and old antibiotics. In this study, <i>Klebsiella pneumoniae</i>, <i>E. coli</i>, and <i>Enterobacter</i> spp. were collected from 10 hospitals in Iran for one year. CRE is recognized by resistance to meropenem and/or imipenem disk after identification of the collected bacteria. Antibiotic susceptibility of CRE against fosfomycin, rifampin, metronidazole, tigecycline, and aztreonam was detected by disk diffusion method and colistin by MIC. In this study, 1222 <i>E. coli</i>, 696 <i>K. pneumoniae</i>, and 621 <i>Enterobacter</i> spp. were collected from 10 hospitals in Iran in one year. Fifty-four <i>E. coli</i> (4.4%), 84 <i>K. pneumoniae</i> (12%), and 51 <i>Enterobacter</i> spp. (8.2%) were CRE. All CRE strains were resistant to metronidazole and rifampicin. Tigecycline has the highest sensitivity on CRE and levofloxacin for <i>Enterobacter</i> spp. Tigecycline showed an acceptable effectiveness rate of sensitivity on the CRE strain. Therefore, we suggest that clinicians consider this valuable antibiotic to treat CRE.</p>\",\"PeriodicalId\":14098,\"journal\":{\"name\":\"International Journal of Microbiology\",\"volume\":\"2023 \",\"pages\":\"8920977\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970715/pdf/\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Microbiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2023/8920977\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2023/8920977","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Antibiotic Susceptibility Patterns for Carbapenem-Resistant Enterobacteriaceae.
Carbapenem is a broad-spectrum beta-lactam antibiotic considered the last choice for the treatment of antibiotic-resistant Gram-negative bacteria. Thus, the increasing rate of carbapenem resistance (CR) in Enterobacteriaceae is an urgent public health threat. This study aimed to evaluate the antibiotic susceptibility pattern of carbapenem-resistant Enterobacteriaceae (CRE) to new and old antibiotics. In this study, Klebsiella pneumoniae, E. coli, and Enterobacter spp. were collected from 10 hospitals in Iran for one year. CRE is recognized by resistance to meropenem and/or imipenem disk after identification of the collected bacteria. Antibiotic susceptibility of CRE against fosfomycin, rifampin, metronidazole, tigecycline, and aztreonam was detected by disk diffusion method and colistin by MIC. In this study, 1222 E. coli, 696 K. pneumoniae, and 621 Enterobacter spp. were collected from 10 hospitals in Iran in one year. Fifty-four E. coli (4.4%), 84 K. pneumoniae (12%), and 51 Enterobacter spp. (8.2%) were CRE. All CRE strains were resistant to metronidazole and rifampicin. Tigecycline has the highest sensitivity on CRE and levofloxacin for Enterobacter spp. Tigecycline showed an acceptable effectiveness rate of sensitivity on the CRE strain. Therefore, we suggest that clinicians consider this valuable antibiotic to treat CRE.
期刊介绍：
International Journal of Microbiology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on microorganisms and their interaction with hosts and the environment. The journal covers all microbes, including bacteria, fungi, viruses, archaea, and protozoa. Basic science will be considered, as well as medical and applied research.
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