表观遗传:对生物学和社会的影响-最近的进展,当前的问题和未来的挑战。

IF 4.8 Q1 GENETICS & HEREDITY
Rodrigo G Arzate-Mejía, Isabelle M Mansuy
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引用次数: 1

摘要

表观遗传是一门新兴的研究学科,旨在研究获得性性状跨代传递的机制。这种传播在植物和无脊椎动物中已经很好地确立,但在哺乳动物中仍然没有很好地表征和了解。重要的问题是,生活经历和环境因素是如何诱发遗传给暴露个体后代的表型变化的,有时是几代连续的,生殖细胞的贡献是什么,对健康和疾病的后果是什么。最近在瑞士z里奇每两年举办一次的“表观遗传:对生物学和社会的影响”研讨会上讨论了这些问题。这篇综述对研讨会期间的研究进行了总结,并讨论了当前该领域未来的重要问题、前景和挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Epigenetic Inheritance: Impact for Biology and Society-recent progress, current questions and future challenges.

Epigenetic Inheritance: Impact for Biology and Society-recent progress, current questions and future challenges.

Epigenetic inheritance has emerged as a new research discipline that aims to study the mechanisms underlying the transmission of acquired traits across generations. Such transmission is well established in plants and invertebrates but remains not well characterized and understood in mammals. Important questions are how life experiences and environmental factors induce phenotypic changes that are passed to the offspring of exposed individuals, sometimes across several successive generations, what is the contribution of germ cells and what are the consequences for health and disease. These questions were recently discussed at the symposium Epigenetic Inheritance: Impact for Biology and Society organized every 2 years in Zürich, Switzerland. This review provides a summary of the research presented during the symposium and discusses current important questions, perspectives and challenges for the field in the future.

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来源期刊
Environmental Epigenetics
Environmental Epigenetics GENETICS & HEREDITY-
CiteScore
6.50
自引率
5.30%
发文量
0
审稿时长
17 weeks
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