[有氧运动中肥胖青少年的肌生长因子]。

Q4 Medicine
Yu V Kasyanova, O V Vasyukova, P L Okorokov, Z T Zuraeva, O B Bezlepkina
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引用次数: 1

摘要

背景:肌因子是由肌细胞合成并释放到血液中的肌肉纤维收缩的反应。它们对碳水化合物和脂质代谢、肌肉质量增长、成骨、增加组织对胰岛素的敏感性、抵消脂肪组织的炎症有积极作用。研究它们的分泌对身体活动(FA)的反应可以帮助个性化肥胖治疗。目的:研究体质外源性肥胖儿童在不同持续时间和强度的体育运动中肌因子的分泌特点,并评价其与身体组成参数的关系。材料与方法:26例儿童(男孩10例,女孩16例)纳入研究15 [13;16岁,SDS BMI: +2.91 [2.24;[3.29],根据Tanner 4-5的说法,性发育。随机分为两组,每组13人。第一组进行不同持续时间的FA(在心率控制的跑步机上行走):30分钟和60分钟,相同强度(小于3代谢当量(MET))。II组-不同强度的FA:低-小于3冰毒,中- 3-6冰毒,相同持续时间为45分钟。使用商业酶免疫测定试剂盒测定肌因子水平。上午空腹,通过生物阻抗分析(韩国770号体分析仪)对机体成分进行评估。使用STATISTICA v.12.0 (StatSoftInc)进行统计处理。美国)。结果以中位数(Me)和四分位数(Q1;Q3)对应25和75个百分位数。结果:中等强度FA导致肌因子水平最大升高:白介素-6 (IL-6)升高215.7%,decorin升高34.3%,鸢尾素水平下降16.5%。一小时的低强度锻炼导致IL-6水平适度上升80.5%,鸢尾素水平下降31.1%。肌肉生长抑制素在60分钟和中等强度的运动后分别平均增加30.9%和31.8%。短时间低强度FA(持续30分钟)不伴有肌因子表达的显著增加。观察FA后肌肉量(r=0.65)、瘦肉量(r=0.62)、无脂量(r=0.64)与decorin水平的关系。体成分参数与IL-6、肌生长抑制素、鸢尾素水平无统计学意义。在基础和刺激肌因子分泌方面没有性别差异。结论:中等强度FA和低强度FA治疗肥胖儿童最有效。30分钟的低强度FN不足以增加骨骼肌肌因子的分泌。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Myokines in obese adolescents with aerobic exercise].

Background: Myokines are synthesized by myocytes and released into the bloodstream in response to muscle fiber contraction. They have a positive effect on carbohydrate and lipid metabolism, muscle mass growth, osteogenesis, increase tissue sensitivity to insulin, counteract inflammation of adipose tissue. The study of their secretion in response to physical activity (FA) can help to personalize the therapy of obesity.

Aim: to study the features of the secretion of myokines in children with constitutionally exogenous obesity during physical activity of different duration and intensity and to evaluate their relationship with the parameters of the body composition.

Materials and methods: 26 children (10 boys and 16 girls) were included in the study 15 [13; 16] years old, SDS BMI: +2.91 [2.24; 3.29], with sexual development according to Tanner 4-5. Two groups of 13 people were formed by random distribution. Group I performed FA (walking on a treadmill under the control of heart rate) of different duration: 30 and 60 minutes at the same intensity (less than 3 metabolic equivalents (MET)). Group II - FA of different intensity: low - less than 3 METH and moderate - 3-6 METH with the same duration of 45 minutes. Commercial kits for enzyme immunoassay were used to determine the level of myokines. The assessment of the compositional composition of the body was carried out by bioimpedance analysis (analyzer In Body 770, South Korea) in the morning, on an empty stomach. Statistical processing was carried out using STATISTICA v.12.0 (StatSoftInc., USA). The results are presented in the form of median (Me) and quartiles (Q1; Q3) corresponding to 25 and 75 percentiles. The critical significance level (p) was assumed to be <0.05.

Results: moderate intensity FA leads to a maximum increase in the level of myokines: interleukin-6 (IL-6) by 215.7% and decorin by 34.3%, a decrease in the level of irisin by 16.5%. An hour-long low-intensity workout leads to a moderate increase in the level of IL-6 by 80.5%, to a decrease in the level of irisin by 31.1%. Myostatin increases equally both after 60-minute FA and after moderate intensity FA by 30.9% and 31.8%, respectively. Short low-intensity FA (lasting 30 minutes) it is not accompanied by a significant increase in the expression of myokines. The relationship between the amount of muscle (r=0.65), lean (r=0.62), fat-free mass (r=0.64) and the level of decorin after FA was noted. There was no statistically significant relationship between the parameters of the body composition and the levels of IL-6, myostatin, and irisin. There were no gender differences in both basal and stimulated myokine secretion.

Conclusion: Moderate intensity FA and low intensity 60-minute FA are most effective for obese children. A 30-minute low-intensity FN is insufficient to increase the secretion of myokines by skeletal muscles.

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来源期刊
Problemy endokrinologii
Problemy endokrinologii Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
1.40
自引率
0.00%
发文量
59
期刊介绍: Since 1955 the “Problems of Endocrinology” (or “Problemy Endocrinologii”) Journal publishes timely articles, balancing both clinical and experimental research, case reports, reviews and lectures on pressing problems of endocrinology. The Journal is aimed to the most topical issues of endocrinology: to chemical structure, biosynthesis and metabolism of hormones, the mechanism of their action at cellular and molecular level; pathogenesis and to clinic of the endocrine diseases, new methods of their diagnostics and treatment. The Journal: features original national and foreign research articles, reflecting world endocrinology development; issues thematic editions on specific areas; publishes chronicle of major international congress sessions and workshops on endocrinology, as well as state-of-the-art guidelines; is intended for scientists, endocrinologists diabetologists and specialists of allied trade, general practitioners, family physicians and pediatrics.
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