比较评估三种广泛使用的用于定量心肌灌注显像缺陷大小的软件包在观察者内和观察者间的可重复性。

IF 0.9 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Hellenic journal of nuclear medicine Pub Date : 2022-09-01 DOI:10.1967/s002449912516

Christos Sachpekidis, Annette Kopp-Schneider, Vasileios Sachpekidis, Efstratios Moralidis

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引用次数: 0

摘要

目的:评价常用的定量测定应激心肌灌注显像异常大小的软件在观察者内和观察者间的可重复性。对象和方法:共有182张应力心肌灌注断层扫描，由经验丰富的和实习的观察者进行两份处理，评估SSSext(总应力评分乘以100/68)和总缺陷程度(TDE)占左心室的百分比，采用4维心肌(4DM)，记忆心脏工具箱(ECTb)和定量灌注SPECT (QPS)包装。采用Bland-Altman (B-A)分析和Lin’s一致性相关系数(CCC)评估一致性。结果:在SSSext的观察者内部可重复性中，CCC显示4DM和QPS的一致性，以及两个观察者对ECTb的一致性。在观察者之间的可重复性中，CCC显示4DM和QPS的一致性很大，而ECTb的一致性很差。关于TDE, CCC在使用所有包装的两名操作员中显示出大量的观察者内重复性，而4DM和QPS的观察者间重复性是可观的，ECTb的观察者间重复性是中等的。在SSSext的4DM、ECTb和QPS的观察者内部重复性中，B-A分析提供的(配对测量的平均±1.96SD)分别为经验丰富的医生0.0±4.3、0.2±7.8、-0.6±7.6和实习生0.2±5.9、0.0±7.5、-0.5±5.4;观察者间重复性分别为0.2±5.4、0.1±9.6、0.2±8.1。在TDE方面，经验阅读者的内部重复性B-A值分别为0.1±5.2、0.1±7.9、0.1±2.8，受训人员为0.3±6.6、-0.1±6.4、-0.1±2.4;在观察员间协议中，B-A分别提供0.6±6.4，-0.2±10.3，-0.1±4.3。结论:使用广泛使用的软件包对缺陷大小进行定量测定时，观察者内部和观察者之间的一致性存在相当大的差异，这表明这些测量方法在临床应用中存在局限性。定量灌注SPECT似乎更可取，但与4DM相比没有明显优势。观察者之间没有显著差异。

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A comparative assessment of intra- and inter- observer repeatability of three widely used software packages for the quantification of defect size in stress myocardial perfusion scintigraphy.

Objective: To assess the intra- and inter-observer repeatability of popular software packages for the quantitative determination of abnormality size in stress myocardial perfusion scintigraphy.

Subjects and methods: A total of 182 tomographic stress myocardial perfusion scans were processed in duplicate by an experienced and trainee observer to assess SSSext (summed stress score multiplied by 100/68) and total defect extent (TDE), as % of the left ventricle, with 4 dimension-myocardial (4DM), emory cardiac toolbox (ECTb) and quantitative perfusion SPECT (QPS) packages. The Bland-Altman (B-A) analysis and Lin's concordance correlation coefficient (CCC) were used to assess agreement.

Results: In SSSext's intra-observer repeatability, CCC showed substantial agreement for 4DM and QPS, and moderate agreement for ECTb for both observers. In inter-observer repeatability, CCC revealed substantial agreement for 4DM and QPS, and poor agreement for ECTb. Regarding TDE, CCC showed substantial intra-observer repeatability for both operators using all packages, while the inter-observer repeatability was substantial for 4DM and QPS, and moderate for ECTb.In SSSext's intra-observer repeatability for 4DM, ECTb and QPS, the B-A analysis provided (mean±1.96SD of paired measurements) 0.0±4.3, 0.2±7.8, -0.6±7.6 for the experienced physician and 0.2±5.9, 0.0±7.5, -0.5±5.4 for the trainee, respectively; in inter-observer repeatability it provided 0.2±5.4, 0.1±9.6, 0.2±8.1, respectively. Regarding TDE, the B-A values for intra-observer repeatability were 0.1±5.2, 0.1±7.9, 0.1±2.8 for the experienced reader and 0.3±6.6, -0.1±6.4, -0.1±2.4 for the trainee, respectively; in inter-observer agreement the B-A provided 0.6±6.4, -0.2±10.3, -0.1±4.3, respectively.

Conclusion: Considerable differences in intra- and inter- observer agreement were noted for the quantitative determination of defect size using widely employed software packages, suggesting limitations in the clinical use of these measurements. Quantitative perfusion SPECT appears preferable, but with no significant advantage over 4DM. There were no significant differences between the observers.

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来源期刊

Hellenic journal of nuclear medicine 医学-核医学

CiteScore

1.40

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： The Hellenic Journal of Nuclear Medicine published by the Hellenic Society of Nuclear Medicine in Thessaloniki, aims to contribute to research, to education and cover the scientific and professional interests of physicians, in the field of nuclear medicine and in medicine in general. The journal may publish papers of nuclear medicine and also papers that refer to related subjects as dosimetry, computer science, targeting of gene expression, radioimmunoassay, radiation protection, biology, cell trafficking, related historical brief reviews and other related subjects. Original papers are preferred. The journal may after special agreement publish supplements covering important subjects, dully reviewed and subscripted separately.