不同溶剂体系山柰抗氧化及抗糖尿病作用的体外研究。

IF 1.4 Q3 Pharmacology, Toxicology and Pharmaceutics
S Vishaka, G Sridevi, J Selvaraj
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引用次数: 1

摘要

山柰(Kaempferia galanga rhizome, KGR)是生姜科的一种无茎、芳香、持久、根茎状的单子叶植物,也被称为沙姜或姜。它具有多种药理作用,本研究的目的是使用几种溶剂溶液来确定KGR的抗氧化和抗糖尿病潜能。通过观察KGR对α -葡萄糖苷酶和α -淀粉酶的抑制活性,评估其体外糖尿病活性。通过2,2-二苯基-1-苦味酰肼试验评价其体外防癌作用。研究结果表明,在100 ~ 500 μg/ml范围内,提取物和标准品对α-淀粉酶和α-葡萄糖苷酶活性的抑制率呈剂量依赖性增加。目前的研究表明,KGR浓缩物可用于糖尿病的治疗以及氧化应激相关疾病的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

An <i>in vitro</i> analysis on the antioxidant and anti-diabetic properties of <i>Kaempferia galanga</i> rhizome using different solvent systems.

An <i>in vitro</i> analysis on the antioxidant and anti-diabetic properties of <i>Kaempferia galanga</i> rhizome using different solvent systems.

An <i>in vitro</i> analysis on the antioxidant and anti-diabetic properties of <i>Kaempferia galanga</i> rhizome using different solvent systems.

An in vitro analysis on the antioxidant and anti-diabetic properties of Kaempferia galanga rhizome using different solvent systems.

Kaempferia galanga rhizome (KGR) is a stemless, sweet-smelling, enduring, and rhizomatous monocotyledonous plant of the ginger family also called sand ginger or kencur. lt possesses many pharmacological effects and the goal of this study is to use several solvent solutions to determine the antioxidant and anti-diabetic potential of KGR. By observing KGR's alpha-glucosidase and alpha-amylase inhibitory activity, the in vitro diabetic activity was assessed. The in vitro cancer preventive action was evaluated by doing the 2,2-diphenyl-1-picrylhydrazyl test. The outcomes of the study showed increase in dose-dependent percentage of inhibition in α-amylase and α-glucosidase activity for both extract and standard ranging from 100 to 500 μg/ml. The current review proposes that the concentrate of KGR could be utilized for the treatment of diabetes mellitus as well with respect to dealing with the oxidative stress-related diseases.

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来源期刊
CiteScore
2.00
自引率
7.10%
发文量
44
审稿时长
20 weeks
期刊介绍: Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is an Official Publication of Society of Pharmaceutical Education & Research™. It is an international journal published Quarterly. Journal of Advanced Pharmaceutical Technology & Research (JAPTR) is available in online and print version. It is a peer reviewed journal aiming to communicate high quality original research work, reviews, short communications, case report, Ethics Forum, Education Forum and Letter to editor that contribute significantly to further the scientific knowledge related to the field of Pharmacy i.e. Pharmaceutics, Pharmacology, Pharmacognosy, Pharmaceutical Chemistry. Articles with timely interest and newer research concepts will be given more preference.
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