从模型到作物的转化研究:植物育种的比较基因组学。

Pub Date : 2023-02-16 DOI:10.5802/crbiol.103
Jérôme Salse
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引用次数: 0

摘要

转化研究的概念起源于20世纪80年代的医学领域,其目的是提高将在一个物种(可视为模型或支点)中获得的研究成果有效地转移到这些成果对其在农业方面的改进感兴趣的所有物种。在此背景下,比较基因组学是翻译研究的重要工具,可以有效地识别控制物种之间共同功能的基因。因此,编辑和表型工具必须允许外推知识的物种内保守基因的功能验证,也就是说转移,并确定最佳等位基因和相关基因型,以便在当前的育种计划中加以利用。
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Translational research from models to crops: comparative genomics for plant breeding.

The concept of translational research, which originated in the medical field in the 1980s, consists in improving the efficient transfer of research results obtained in a species (which can be considered as a model or pivot) to all the species for which these results are of interest for its improvement in Agriculture. In this context, comparative genomics is an important tool for translational research, effectively identifying genes controlling common functions between species. Editing and phenotyping tools must thus allow the functional validation of the gene conserved within the species for which the knowledge has been extrapolated, that is to say transferred, and the identification of the best alleles and associated genotypes for exploitation in current breeding programs.

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