涎腺导管内癌:183例报告病例如何纳入发展中的分类。

IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
ACS Applied Materials & Interfaces Pub Date : 2023-03-01 Epub Date: 2022-08-30 DOI:10.1097/PAP.0000000000000362
Lester D R Thompson, Justin A Bishop
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引用次数: 2

摘要

涎腺导管内癌(IDC)是一组非常罕见的肿瘤。许多名称、诊断标准的变化和新观察到的分子发现(包括NCOA4::RET、TRIM27::RET,HRAS点突变和PIK3CA通路改变)在识别和分类这组肿瘤方面产生了进一步的混乱。不同的组织学表现和生长模式表明有不止一种肿瘤类型,可见插管、顶泌、嗜酸细胞和混合特征。坦率地说,破坏性侵犯使这一类别更加复杂,因为“导管内”这个名字意味着“原位”肿瘤。最近关于融合阳性IDC的证据表明,导管和肌上皮细胞都有相同的分子基础,这有助于进一步分离这些肿瘤。本文总结了IDC旗下183种肿瘤的历史分组,并强调了其独特的组织学、免疫组织化学和分子特征,这些特征可能进一步指导命名标准化和统一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Salivary Gland Intraductal Carcinoma: How Do 183 Reported Cases Fit Into a Developing Classification.

Salivary gland intraductal carcinoma (IDC) is a very uncommon group of neoplasms. Many names, variations in diagnostic criteria, and newly observed molecular findings (including NCOA4 :: RET , TRIM27 :: RET , HRAS point mutations, and PIK3CA pathway alterations) have generated further confusion in being able to recognize and categorize this group of tumors. Different histologic appearances and patterns of growth suggest there is more than one tumor category, with intercalated duct, apocrine, oncocytic, and hybrid features seen. Frankly destructive invasion further complicates the category, as the name "intraductal" would suggest an "in situ" neoplasm. Recent evidence on fusion-positive IDC demonstrates the same molecular underpinnings in both the ductal and the myoepithelial cells, which aids in further separating these tumors. This article summarizes the historical group of 183 neoplasms classified under the umbrella of IDC and highlights the unique histologic, immunohistochemistry, and molecular features that may further guide nomenclature standardization and harmonization.

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来源期刊
ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces 工程技术-材料科学:综合
CiteScore
16.00
自引率
6.30%
发文量
4978
审稿时长
1.8 months
期刊介绍: ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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