Hepcidin和铁在健康和疾病中的作用。

IF 15.1 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Elizabeta Nemeth, Tomas Ganz
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引用次数: 29

摘要

铁调节激素Hepcidin决定血浆铁浓度和全身铁含量。Hepcidin由肝细胞分泌,其功能是控制细胞铁出口国铁转运蛋白的活性,铁转运蛋白将铁从肠道铁吸收和铁储存中输送到血浆中。血浆中Hepcidin浓度因铁负荷和炎症而升高,并在促红细胞生成和妊娠期间受到抑制。Hepcidin缺乏症导致血色素沉着症和贫血伴无效的红细胞生成。Hepcidin过量会导致铁限制性贫血,包括炎症性贫血。hepcidin诊断和治疗激动剂和拮抗剂的发展应改善铁疾病的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Hepcidin and Iron in Health and Disease.

Hepcidin and Iron in Health and Disease.

Hepcidin and Iron in Health and Disease.

Hepcidin, the iron-regulatory hormone, determines plasma iron concentrations and total body iron content. Hepcidin, secreted by hepatocytes, functions by controlling the activity of the cellular iron exporter ferroportin, which delivers iron to plasma from intestinal iron absorption and from iron stores. Hepcidin concentration in plasma is increased by iron loading and inflammation and is suppressed by erythropoietic stimulation and during pregnancy. Hepcidin deficiency causes iron overload in hemochromatosis and anemias with ineffective erythropoiesis. Hepcidin excess causes iron-restrictive anemias including anemia of inflammation. The development of hepcidin diagnostics and therapeutic agonists and antagonists should improve the treatment of iron disorders.

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来源期刊
Annual review of medicine
Annual review of medicine 医学-医学:内科
CiteScore
24.90
自引率
0.00%
发文量
58
期刊介绍: The Annual Review of Medicine, which has been published since 1950, focuses on important advancements in diverse areas of medicine. These include AIDS/HIV, cardiology, clinical pharmacology, dermatology, endocrinology/metabolism, gastroenterology, genetics, immunology, infectious disease, neurology, oncology/hematology, pediatrics, psychiatry, pulmonology, reproductive medicine, and surgery. The journal's current volume has transitioned from a gated access model to an open access model through the Annual Reviews' Subscribe to Open program. All articles published in the journal are now available under a CC BY license.
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