补骨脂活性类黄酮化合物“茯苓素”在医学领域的生物学意义、疗效及分析研究

Q3 Pharmacology, Toxicology and Pharmaceutics
Dinesh Kumar Patel
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引用次数: 0

摘要

背景:黄酮类植物化学物质是次生代谢物的最好例子,存在于不同的天然来源中,包括水果、谷物、蔬菜、西兰花、茶、浆果、葡萄酒、草莓、苹果、葡萄、生菜和柑橘类水果。天然产品是黄酮类化合物的丰富来源,存在于我们的饮食来源。目的:黄酮类化合物按其基本化学结构可分为查尔酮、异黄酮、黄酮醇、儿茶素、黄酮、黄烷酮和花青素。补骨脂属豆科植物,是一种用于治疗炎症性疾病、细菌感染和癌症疾病的中药。方法:从不同的数据库中收集科学数据并进行分析,以发现科络素在医学上的治疗潜力。检索了不同的科学数据库,如Google, Scopus, PubMed, Science Direct等,以收集所需的corylin科学信息。本工作收集了有关科连蛋白的科学资料,以了解科连蛋白在科学领域的药理活性和药用价值。然而,为规范补骨脂及其他药用植物,还收集和分析了茯苓素的分析技术数据。结果:通过对研究成果的科学数据分析,揭示了补骨脂的药用价值及其重要植物成分茯苓素的药用价值。科学数据分析表明,在补骨脂(Psoralea corylifolia L.)果仁中发现的一种类黄酮类植物化学物质,在骨分化、骨生长和骨质疏松症中的生物学重要性已被本科学研究证实。抗炎、抗氧化和抗肿瘤活性也在医学文献中有所描述。在高脂血症、胰岛素抵抗、动脉粥样硬化、肝细胞癌和神经系统疾病中的生物学重要性也在这项工作中被提出。结论:通过科学的数据分析,揭示了科里林在医学领域的生物学重要性和治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biological Importance, Therapeutic Benefits, and Analytical Aspects of Active Flavonoidal Compounds 'Corylin' from Psoralea corylifolia in the Field of Medicine.
BACKGROUND Flavonoidal class phytochemicals are the best examples of secondary metabolite found to be present in the different natural sources, including 'fruits, grains, vegetables, broccoli, tea, berries, wine, strawberries, apple, grapes, lettuce and citrus fruit. Natural products are the rich source of flavonoidal compounds present in our diet source. OBJECTIVE Flavonoidal class chemical can be sub categorized into chalcones, isoflavone, flavonols, catechin, flavones, flavanones, and anthocyanidin with respect to their basic chemical structures. Psoralea corylifolia L. belongs to the family Fabaceae is an herbal medicine used in traditional Chinese Medicine for the treatment of inflammatory disorders, bacterial infections and cancerous disorders. METHODS In the present work, scientific data has been collected from different databases and analyzed in order to know the therapeutic potential of corylin in medicine. Different scientific databases such as Google, Scopus, PubMed, Science Direct etc., have been searched to collect the needed scientific information of corylin. Scientific information of corylin has been collected in the present work in order to know the pharmacological activities and medicinal uses of corylin in the scientific fields. However, analytical techniques data of corylin have also been collected and analyzed for standardization of Psoralea corylifolia and other medicinal plants. RESULTS Scientific data analysis of research works revealed the medicinal importance of Psoralea corylifolia and its important phytoconstituents corylin in the medicine. Scientific data analysis revealed that corylin is a flavonoidal class phytochemical found to be present in the nuts of Psoralea corylifolia L. Biological importance of corylin in bone differentiation, bone growth, osteoporosis have been proven in the scientific research work. Anti-inflammatory, anti-oxidant and antitumor activity of corylin has been also mentioned in the medicine. Biological importances of corylin in hyperlipidemia, insulin resistance, atherosclerosis, hepatocellular carcinoma and neurodisorders have also been presented in this work. CONCLUSION Scientific data analysis revealed the biological importance and therapeutic potential of corylin in the medicine.
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来源期刊
Infectious disorders drug targets
Infectious disorders drug targets Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
3.10
自引率
0.00%
发文量
123
期刊介绍: Infectious Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in infectious disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in infectious disorders. As the discovery, identification, characterization and validation of novel human drug targets for anti-infective drug discovery continues to grow, this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.
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