脂肪细胞信号通过下调TTF-2/FOXE1影响甲状腺特异性基因的表达。

IF 3.6 4区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of molecular endocrinology Pub Date : 2022-12-12 Print Date: 2023-01-01 DOI:10.1530/JME-22-0129

Michela Zamboni, Georgios Strimpakos, Eleonora Poggiogalle, Lorenzo Maria Donini, Donato Civitareale

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引用次数: 0

摘要

肥胖会影响甲状腺功能。甲状腺功能减退、甲状腺结节、甲状腺肿和甲状腺癌症在BMI值较高的患者中更常见。尽管这些数据得到了许多临床和流行病学研究的支持，但我们在分子水平上的知识非常匮乏。在这项研究中，我们首次提出了脂肪细胞信号下调甲状腺特异性转录因子2（TTF-2/FoxE1）表达的实验证据。它在甲状腺发育和甲状腺稳态中起着至关重要的作用，也与甲状腺癌症密切相关。我们提供了体内和体外证据，证明TTF-2/FoxE1基因表达的抑制是由脂肪细胞信号介导的。

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Adipocyte signaling affects thyroid-specific gene expression via down-regulation of TTF-2/FOXE1.

Obesity affects thyroid gland function. Hypothyroidism, thyroid nodules, goiter, and thyroid cancer are more frequent in patients with higher BMI values. Although these data are supported by many clinical and epidemiological studies, our knowledge is very scarce at the molecular level. In this study, we present the first experimental evidence that adipocyte signaling downregulates the expression of thyroid-specific transcription factor 2 (TTF-2/FoxE1). It plays a crucial role in thyroid development and thyroid homeostasis and it is strictly connected to thyroid cancer as well. We provide in vivo and in vitro evidence that inhibition of TTF-2/FoxE1 gene expression is mediated by adipocyte signaling.

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来源期刊

Journal of molecular endocrinology 医学-内分泌学与代谢

CiteScore

6.90

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Molecular Endocrinology is an official journal of the Society for Endocrinology and is endorsed by the European Society of Endocrinology and the Endocrine Society of Australia. Journal of Molecular Endocrinology is a leading global journal that publishes original research articles and reviews. The journal focuses on molecular and cellular mechanisms in endocrinology, including: gene regulation, cell biology, signalling, mutations, transgenics, hormone-dependant cancers, nuclear receptors, and omics. Basic and pathophysiological studies at the molecule and cell level are considered, as well as human sample studies where this is the experimental model of choice. Technique studies including CRISPR or gene editing are also encouraged.