流量低至5 nL/min的校准方法和验证方法。

IF 1.3 4区医学 Q4 ENGINEERING, BIOMEDICAL

Biomedical Engineering / Biomedizinische Technik Pub Date : 2023-02-23 DOI:10.1515/bmt-2022-0049

Chris Mills, Elsa Batista, Hugo Bissig, Florestan Ogheard, Abir Wissam Boudaoud, Oliver Büker, Krister Stolt, John Morgan, Sabrina Kartmann, Kerstin Thiemann, Guilherme Miotto, Anders Niemann, Stephan Klein, Gijs Ratering, Joost Lötters

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引用次数: 1

摘要

在一些活动领域，特别是在医疗应用中，提高现有药物输送装置和以非常低的流速工作的在线传感器的体积、流量和压力的准确性并实现可追踪测量是必不可少的。这只能通过开发新的校准方法和扩展现有的计量基础设施来实现，以执行微流和纳米流测量。在本文中，我们将研究用于测量流量的新的可追溯技术，从5 nL/min到1,500 nL/min，并提供九个实验室之间的相互比较结果，用于校准两种不同的流量计和注射泵。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Calibration methods for flow rates down to 5 nL/min and validation methodology.

Improving the accuracy and enabling traceable measurements of volume, flow, and pressure in existing drug delivery devices and in-line sensors operating at very low flow rates is essential in several fields of activities and specially in medical applications. This can only be achieved through the development of new calibrationmethods and by expanding the existing metrological infrastructure to perform micro-flow and nano-flow measurements. In this paper, we will investigate new traceable techniques for measuring flow rate, from 5 nL/min to 1,500 nL/min and present the results of an inter-comparison between nine laboratories for the calibration of two different flow meters and a syringe pump.

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来源期刊

Biomedical Engineering / Biomedizinische Technik 医学-工程：生物医学

CiteScore

3.50

自引率

5.90%

发文量

审稿时长

2-3 weeks

期刊介绍： Biomedical Engineering / Biomedizinische Technik (BMT) is a high-quality forum for the exchange of knowledge in the fields of biomedical engineering, medical information technology and biotechnology/bioengineering. As an established journal with a tradition of more than 60 years, BMT addresses engineers, natural scientists, and clinicians working in research, industry, or clinical practice.