脊柱裂:遗传学、病理生理学和新兴细胞疗法的综述。

IF 2.2 Q3 DEVELOPMENTAL BIOLOGY

Journal of Developmental Biology Pub Date : 2022-06-06 DOI:10.3390/jdb10020022

Abd-Elrahman Said Hassan, Yimeng Lina Du, Su Yeon Lee, Aijun Wang, Diana Lee Farmer

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引用次数: 7

摘要

脊柱裂是最常见的先天性中枢神经系统缺陷，对那些受其折磨的人来说可能预示着终身残疾。虽然这种疾病的完整基础尚未完全了解，但在这种疾病的遗传和分子基础方面已经取得了巨大进展。此外，脊柱裂的治疗已经取得了很大的进步，从出生后的手术闭合缺陷到现在最先进的子宫内修复。这篇综述将涉及到遗传学、胚胎学和病理生理学，最后讨论当前的治疗方法，以及fda批准的第一个利用干细胞治疗脊柱裂的临床试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Spina Bifida: A Review of the Genetics, Pathophysiology and Emerging Cellular Therapies.

Spina bifida is the most common congenital defect of the central nervous system which can portend lifelong disability to those afflicted. While the complete underpinnings of this disease are yet to be fully understood, there have been great advances in the genetic and molecular underpinnings of this disease. Moreover, the treatment for spina bifida has made great advancements, from surgical closure of the defect after birth to the now state-of-the-art intrauterine repair. This review will touch upon the genetics, embryology, and pathophysiology and conclude with a discussion on current therapy, as well as the first FDA-approved clinical trial utilizing stem cells as treatment for spina bifida.

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来源期刊

Journal of Developmental Biology Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

4.10

自引率

18.50%

发文量

审稿时长

11 weeks

期刊介绍： The Journal of Developmental Biology (ISSN 2221-3759) is an international, peer-reviewed, quick-refereeing, open access journal, which publishes reviews, research papers and communications on the development of multicellular organisms at the molecule, cell, tissue, organ and whole organism levels. Our aim is to encourage researchers to effortlessly publish their new findings or concepts rapidly in an open access medium, overseen by their peers. There is no restriction on the length of the papers; the full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. Journal of Developmental Biology focuses on: -Development mechanisms and genetics -Cell differentiation -Embryonal development -Tissue/organism growth -Metamorphosis and regeneration of the organisms. It involves many biological fields, such as Molecular biology, Genetics, Physiology, Cell biology, Anatomy, Embryology, Cancer research, Neurobiology, Immunology, Ecology, Evolutionary biology.