Oguzhan Ilden, Omer Tarik Selcuk, Hamit Yasar Ellidag, Nursel Türkoglu Selcuk, Hulya Eyigor, Levent Renda, Unal Gökalp Isik, Hande Konsuk Unlü, Ustün Osma, Mustafa Deniz Yılmaz, Esin Eren, Necat Yilmaz
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引用次数: 0
摘要
目的：信号肽CUB-EGF结构域含蛋白1（SCUBE-1）是一种细胞表面蛋白，炎症会导致其在血清中的含量增加。本研究旨在比较 OSA 患者的血清 SCUBE-1 水平，并研究 CPAP 治疗对血清 SCUBE-1 的影响：方法：从 61 名严重 OSA 患者和 25 名被评估为简单打鼾的对照组受试者中采集血样。61 名严重 OSA 患者接受了 CPAP 治疗，并在 1 年后进行了随访。CPAP 治疗 1 年后进行评估：结果：严重 OSA 患者的血清 SCUBE-1 值明显升高。结果：严重 OSA 患者的血清 SCUBE-1 值明显升高，使用 CPAP 治疗后 SCUBE-1 值明显降低：OSA患者的血清SCUBE-1值显示，CPAP治疗1年后，SCUBE-1水平明显下降。
An evaluation of the change in serum SCUBE-1 levels with CPAP treatment in patients with severe obstructive sleep apnea.
Objective: Signal peptide CUB-EGF domain-containing protein 1 (SCUBE-1) is a cell surface protein, wherein inflammation causes an increase in serum. The aim of this study was to compare serum SCUBE-1 levels in OSA patients and to investigate the serum SCUBE-1 change with CPAP treatment.
Methods: Blood samples were obtained from 61 severe OSA patients and from 25 control subjects evaluated as simple snorers. The 61 patients with severe OSA were treated with CPAP therapy and were recalled for follow up after 1 year. Evaluation was made after 1 year of CPAP therapy.
Results: Serum SCUBE-1 values were significantly higher in patients with severe OSA. The SCUBE-1 values significantly decreased after treatment with CPAP.
Conclusion: Serum SCUBE-1 values in OSA patients showed a significant reduction in SCUBE-1 levels following 1 year of CPAP treatment.
期刊介绍：
CRANIO: The Journal of Craniomandibular & Sleep Practice is the oldest and largest journal in the world devoted to temporomandibular disorders, and now also includes articles on all aspects of sleep medicine. The Journal is multidisciplinary in its scope, with editorial board members from all areas of medicine and dentistry, including general dentists, oral surgeons, orthopaedists, radiologists, chiropractors, professors and behavioural scientists, physical therapists, acupuncturists, osteopathic and ear, nose and throat physicians.
CRANIO publishes commendable works from outstanding researchers and clinicians in their respective fields. The multidisciplinary format allows individuals practicing with a TMD emphasis to stay abreast of related disciplines, as each issue presents multiple topics from overlapping areas of interest.
CRANIO''s current readership (thousands) is comprised primarily of dentists; however, many physicians, physical therapists, chiropractors, osteopathic physicians and other related specialists subscribe and contribute to the Journal.
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