弥漫性胸膜间皮瘤：分子发病机制、诊断和治疗进展。

IF 11.2 1区医学 Q1 PHARMACOLOGY & PHARMACY

Annual review of pharmacology and toxicology Pub Date : 2024-01-24 Epub Date: 2023-09-18 DOI:10.1146/annurev-pathol-042420-092719

Christopher A Febres-Aldana, Rachel Fanaroff, Michael Offin, Marjorie G Zauderer, Jennifer L Sauter, Soo-Ryum Yang, Marc Ladanyi

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引用次数: 0

摘要

弥漫性胸膜间皮瘤（DPM）是一种由胸膜表面间皮细胞引起的高度侵袭性恶性肿瘤。虽然DPM是一种公认的与石棉暴露有关的疾病，但最近的进展扩大了我们对分子发病机制的理解，并改变了我们的临床实践。这篇全面的综述探讨了DPM的当前概念和新趋势，包括风险因素、病理生物学、组织学分型和治疗管理，重点是对这种复杂疾病的多学科方法。《病理学年度评论：疾病机制》第19卷预计最终在线出版日期为2024年1月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Diffuse Pleural Mesothelioma: Advances in Molecular Pathogenesis, Diagnosis, and Treatment.

Diffuse pleural mesothelioma (DPM) is a highly aggressive malignant neoplasm arising from the mesothelial cells lining the pleural surfaces. While DPM is a well-recognized disease linked to asbestos exposure, recent advances have expanded our understanding of molecular pathogenesis and transformed our clinical practice. This comprehensive review explores the current concepts and emerging trends in DPM, including risk factors, pathobiology, histologic subtyping, and therapeutic management, with an emphasis on a multidisciplinary approach to this complex disease.

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来源期刊

Annual review of pharmacology and toxicology 医学-毒理学

CiteScore

27.80

自引率

0.00%

发文量

期刊介绍： Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.