肠道炎症免疫反应的活体成像。

IF 5 3区 医学 Q2 IMMUNOLOGY
Masaki Honda, Masashi Kadohisa, Daiki Yoshii, Yoshihiro Komohara, Taizo Hibi
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引用次数: 1

摘要

迄今为止,已经鉴定了许多种类的免疫细胞,但它们在肠道免疫中的确切作用仍不清楚。了解这些免疫细胞的体内行为及其在胃肠道炎症中的功能,包括结肠炎、炎症性肠病、缺血-再灌注损伤和中性粒细胞胞外陷阱,对于胃肠研究进入下一步至关重要。此外,了解胃肠道肿瘤和组织修复中涉及的免疫反应对于阐明未知的疾病机制变得越来越重要。近年来,活体显微镜在胃肠道研究中的应用为肠道特异性事件(包括先天免疫和适应性免疫)的机制提供了新的见解。在这篇综述中,我们重点介绍了活体成像在胃肠道研究中的新兴作用,并描述了如何使用活体显微镜观察肠道和免疫细胞。此外,我们概述了这项新技术获得的新发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Intravital imaging of immune responses in intestinal inflammation.

Intravital imaging of immune responses in intestinal inflammation.

Intravital imaging of immune responses in intestinal inflammation.

Intravital imaging of immune responses in intestinal inflammation.

To date, many kinds of immune cells have been identified, but their precise roles in intestinal immunity remain unclear. Understanding the in vivo behavior of these immune cells and their function in gastrointestinal inflammation, including colitis, inflammatory bowel disease, ischemia-reperfusion injury, and neutrophil extracellular traps, is critical for gastrointestinal research to proceed to the next step. Additionally, understanding the immune responses involved in gastrointestinal tumors and tissue repair is becoming increasingly important for the elucidation of disease mechanisms that have been unknown. In recent years, the application of intravital microscopy in gastrointestinal research has provided novel insights into the mechanisms of intestine-specific events including innate and adaptive immunities. In this review, we focus on the emerging role of intravital imaging in gastrointestinal research and describe how to observe the intestines and immune cells using intravital microscopy. Additionally, we outline novel findings obtained by this new technique.

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来源期刊
CiteScore
11.10
自引率
1.20%
发文量
45
审稿时长
11 weeks
期刊介绍: Inflammation and Regeneration is the official journal of the Japanese Society of Inflammation and Regeneration (JSIR). This journal provides an open access forum which covers a wide range of scientific topics in the basic and clinical researches on inflammation and regenerative medicine. It also covers investigations of infectious diseases, including COVID-19 and other emerging infectious diseases, which involve the inflammatory responses. Inflammation and Regeneration publishes papers in the following categories: research article, note, rapid communication, case report, review and clinical drug evaluation.
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