角膜上皮的发育和体内平衡

IF 2.2 3区生物学 Q4 CELL BIOLOGY

Differentiation Pub Date : 2023-07-01 DOI:10.1016/j.diff.2023.02.002

Shivalingappa K. Swamynathan , Sudha Swamynathan

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引用次数: 0

摘要

角膜上皮（CE）是眼睛最前部的细胞结构，是一种自我更新的分层鳞状组织，保护眼睛的其他部分免受外部因素的影响。在这个精致的三维结构中，每个细胞都需要有适当的极性和位置意识，才能使CE成为透明、折射和保护性组织。最近的研究已经开始阐明参与胚胎发育、产后成熟和CE稳态的分子和细胞事件，以及它们是如何被协调良好的转录因子网络调节的。这篇综述总结了相关知识的现状，旨在深入了解CE发育和/或稳态中断引起的疾病的病理生理学。

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Corneal epithelial development and homeostasis

The corneal epithelium (CE), the most anterior cellular structure of the eye, is a self-renewing stratified squamous tissue that protects the rest of the eye from external elements. Each cell in this exquisite three-dimensional structure needs to have proper polarity and positional awareness for the CE to serve as a transparent, refractive, and protective tissue. Recent studies have begun to elucidate the molecular and cellular events involved in the embryonic development, post-natal maturation, and homeostasis of the CE, and how they are regulated by a well-coordinated network of transcription factors. This review summarizes the status of related knowledge and aims to provide insight into the pathophysiology of disorders caused by disruption of CE development, and/or homeostasis.

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来源期刊

Differentiation 生物-发育生物学

CiteScore

4.10

自引率

3.40%

发文量

审稿时长

51 days

期刊介绍： Differentiation is a multidisciplinary journal dealing with topics relating to cell differentiation, development, cellular structure and function, and cancer. Differentiation of eukaryotes at the molecular level and the use of transgenic and targeted mutagenesis approaches to problems of differentiation are of particular interest to the journal. The journal will publish full-length articles containing original work in any of these areas. We will also publish reviews and commentaries on topics of current interest. The principal subject areas the journal covers are: • embryonic patterning and organogenesis • human development and congenital malformation • mechanisms of cell lineage commitment • tissue homeostasis and oncogenic transformation • establishment of cellular polarity • stem cell differentiation • cell reprogramming mechanisms • stability of the differentiated state • cell and tissue interactions in vivo and in vitro • signal transduction pathways in development and differentiation • carcinogenesis and cancer • mechanisms involved in cell growth and division especially relating to cancer • differentiation in regeneration and ageing • therapeutic applications of differentiation processes.