动态超低稀释的芦丁破坏质膜组织,减少黑色素瘤癌细胞的迁移。

IF 3.3 3区 生物学 Q3 CELL BIOLOGY
Camille Fuselier, Eleonore Dufay, Alexandre Berquand, Christine Terryn, Arnaud Bonnomet, Michael Molinari, Laurent Martiny, Christophe Schneider
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引用次数: 0

摘要

皮肤黑色素瘤是一种癌症,其预后非常差,主要是因为转移扩散,因此细胞迁移失调。目前的治疗方法可以受益于补充药物作为肿瘤学的支持性护理。在我们的研究中,我们发现Ruta Graveolens的动态超低稀释可在体外抑制B16F10黑色素瘤细胞的纤连蛋白迁移,并减少体内转移扩散。这些影响似乎是由于质膜组织的破坏,细胞和膜硬度的变化,与肌动蛋白细胞骨架的紊乱和质膜脂质组成的改变有关。总之,这些结果在皮肤黑色素瘤的体外和体内模型中证明了Ruta graveolens超低动态稀释的抗癌和抗转移活性,并加强了其作为肿瘤学补充药物的兴趣。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Dynamized ultra-low dilution of <i>Ruta graveolens</i> disrupts plasma membrane organization and decreases migration of melanoma cancer cell.

Dynamized ultra-low dilution of <i>Ruta graveolens</i> disrupts plasma membrane organization and decreases migration of melanoma cancer cell.

Dynamized ultra-low dilution of <i>Ruta graveolens</i> disrupts plasma membrane organization and decreases migration of melanoma cancer cell.

Dynamized ultra-low dilution of Ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell.

Cutaneous melanoma is a cancer with a very poor prognosis mainly because of metastatic dissemination and therefore a deregulation of cell migration. Current therapies can benefit from complementary medicines as supportive care in oncology. In our study, we show that a dynamized ultra-low dilution of Ruta Graveolens leads to an in vitro inhibition of migration on fibronectin of B16F10 melanoma cells, as well as a decrease in metastatic dissemination in vivo. These effects appear to be due to a disruption of plasma membrane organization, with a change in cell and membrane stiffness, associated with a disorganization of the actin cytoskeleton and a modification of the lipid composition of the plasma membrane. Together, these results demonstrate, in in vitro and in vivo models of cutaneous melanoma, an anti-cancer and anti-metastatic activity of ultra-low dynamized dilution of Ruta graveolens and reinforce its interest as complementary medicine in oncology.

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来源期刊
CiteScore
6.40
自引率
0.00%
发文量
7
审稿时长
53 weeks
期刊介绍: Cell Adhesion & Migration is a multi-disciplinary, peer reviewed open access journal that focuses on the biological or pathological implications of cell-cell and cell-microenvironment interactions. The main focus of this journal is fundamental science. The journal strives to serve a broad readership by regularly publishing review articles covering specific disciplines within the field, and by publishing focused issues that provide an overview on specific topics of interest within the field. Cell Adhesion & Migration publishes relevant and timely original research, as well as authoritative overviews, commentaries, and perspectives, providing context for the work presented in Cell Adhesion & Migration and for key results published elsewhere. Original research papers may cover all topics important in the field of cell-cell and cell-matrix interactions. Cell Adhesion & Migration also publishes articles related to cell biomechanics, biomaterial, and development of related imaging technologies.
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