心肌梗死后心脏伤口愈合的反应。

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Upendra Chalise, Mediha Becirovic-Agic, Merry L Lindsey
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引用次数: 6

摘要

心肌梗死(MI)被定义为心肌坏死与长时间缺血一致的证据。心肌对心肌梗死的反应是,心肌经历一系列的伤口愈合事件,开始炎症并转变为抗炎症,然后过渡到组织修复,最终形成疤痕以取代坏死心肌区域。心肌梗死的总体反应由两个主要步骤决定,第一个步骤是通过浸润的白细胞分泌蛋白酶来分解细胞外基质(ECM)成分,这是去除坏死心肌细胞的必要步骤。第二步是生成新的ECM,包括疤痕;这个步骤是由心脏成纤维细胞控制的,它是新ECM合成的主要来源。白细胞成分位于两步过程的中间,在白细胞从促炎细胞表型向抗炎细胞表型和修复细胞表型转变的过程中,对两者都有贡献。这两个步骤之间的平衡决定了最终形成的疤痕的数量和质量,这反过来又有助于心肌梗死后的慢性结局,包括进展为心力衰竭。这篇综述将总结我们目前关于心肌梗死的心脏伤口愈合反应的知识,主要集中在小鼠心肌梗死的实验模型上。本文分类如下:心血管疾病>分子与细胞生理学>免疫系统疾病>分子与细胞生理学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The cardiac wound healing response to myocardial infarction.

The cardiac wound healing response to myocardial infarction.

The cardiac wound healing response to myocardial infarction.

The cardiac wound healing response to myocardial infarction.

Myocardial infarction (MI) is defined as evidence of myocardial necrosis consistent with prolonged ischemia. In response to MI, the myocardium undergoes a series of wound healing events that initiate inflammation and shift to anti-inflammation before transitioning to tissue repair that culminates in scar formation to replace the region of the necrotic myocardium. The overall response to MI is determined by two major steps, the first of which is the secretion of proteases by infiltrating leukocytes to breakdown extracellular matrix (ECM) components, a necessary step to remove necrotic cardiomyocytes. The second step is the generation of new ECM that comprises the scar; and this step is governed by the cardiac fibroblasts as the major source of new ECM synthesis. The leukocyte component resides in the middle of the two-step process, contributing to both sides as the leukocytes transition from pro-inflammatory to anti-inflammatory and reparative cell phenotypes. The balance between the two steps determines the final quantity and quality of scar formed, which in turn contributes to chronic outcomes following MI, including the progression to heart failure. This review will summarize our current knowledge regarding the cardiac wound healing response to MI, primarily focused on experimental models of MI in mice. This article is categorized under: Cardiovascular Diseases > Molecular and Cellular Physiology Immune System Diseases > Molecular and Cellular Physiology.

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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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