高血栓STEMIs的预扩张球囊:紧急经皮冠状动脉血运重建术患者慢流/无再流的独立预测因子

IF 1.6 3区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Rajesh Kumar, Danish Qayyum, Ifikhar Ahmed, Lajpat Rai, Ayaz Mir, Romana Awan, Ali Bin Naseer, Abdul Basit, Jawaid Akbar Sial, Tahir Saghir, Nadeem Qamar, Musa Karim
{"title":"高血栓STEMIs的预扩张球囊:紧急经皮冠状动脉血运重建术患者慢流/无再流的独立预测因子","authors":"Rajesh Kumar,&nbsp;Danish Qayyum,&nbsp;Ifikhar Ahmed,&nbsp;Lajpat Rai,&nbsp;Ayaz Mir,&nbsp;Romana Awan,&nbsp;Ali Bin Naseer,&nbsp;Abdul Basit,&nbsp;Jawaid Akbar Sial,&nbsp;Tahir Saghir,&nbsp;Nadeem Qamar,&nbsp;Musa Karim","doi":"10.1155/2023/4012361","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Distal embolization due to microthrombus fragments formed during predilation ballooning is considered one of the possible mechanisms of slow flow/no-reflow (SF/NR). Therefore, this study aimed to compare the incidence of intraprocedure SF/NR during the primary percutaneous coronary intervention (PCI) in patients with high thrombus burden (≥4 grade) with and without predilation ballooning for culprit lesion preparation. <i>Methodology</i>. This prospective descriptive cross-sectional study included patients with a high thrombus burden (≥4 grades) who underwent primary PCI. Propensity-matched cohorts of patients with and without predilation ballooning in a 1 : 1 ratio were compared for the incidence of intraprocedure SF/NR.</p><p><strong>Results: </strong>A total of 765 patients with high thrombus burden undergoing primary PCI were included in this study. The mean age was 55.75 ± 11.54 years, and 78.6% (601) were males. Predilation ballooning was conducted in 346 (45.2%) patients. The incidence of intraprocedure SF/NR was significantly higher (41.3% vs. 27.4%; <i>p</i> < 0.001) in patients with predilation ballooning than in those without preballooning, respectively. The incidence of intraprocedure SF/NR also remained significantly higher for the predilation ballooning cohort with an incidence rate of 41.3% as against 30.1% (<i>p</i>=0.002) for the propensity-matched cohort of patients without predilation ballooning with a relative risk of 1.64 (95% CI: 1.20 to 2.24). Moreover, the in-hospital mortality rate remained higher but insignificant, among patients with and without predilation ballooning (8.1% vs. 4.9%; <i>p</i>=0.090).</p><p><strong>Conclusion: </strong>In conclusion, predilation ballooning can be associated with an increased risk of incidence of intraprocedure SF/NR during primary PCI in patients with high thrombus burden.</p>","PeriodicalId":16329,"journal":{"name":"Journal of interventional cardiology","volume":"2023 ","pages":"4012361"},"PeriodicalIF":1.6000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839408/pdf/","citationCount":"3","resultStr":"{\"title\":\"Predilation Ballooning in High Thrombus Laden STEMIs: An Independent Predictor of Slow Flow/No-Reflow in Patients Undergoing Emergent Percutaneous Coronary Revascularization.\",\"authors\":\"Rajesh Kumar,&nbsp;Danish Qayyum,&nbsp;Ifikhar Ahmed,&nbsp;Lajpat Rai,&nbsp;Ayaz Mir,&nbsp;Romana Awan,&nbsp;Ali Bin Naseer,&nbsp;Abdul Basit,&nbsp;Jawaid Akbar Sial,&nbsp;Tahir Saghir,&nbsp;Nadeem Qamar,&nbsp;Musa Karim\",\"doi\":\"10.1155/2023/4012361\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Distal embolization due to microthrombus fragments formed during predilation ballooning is considered one of the possible mechanisms of slow flow/no-reflow (SF/NR). Therefore, this study aimed to compare the incidence of intraprocedure SF/NR during the primary percutaneous coronary intervention (PCI) in patients with high thrombus burden (≥4 grade) with and without predilation ballooning for culprit lesion preparation. <i>Methodology</i>. This prospective descriptive cross-sectional study included patients with a high thrombus burden (≥4 grades) who underwent primary PCI. Propensity-matched cohorts of patients with and without predilation ballooning in a 1 : 1 ratio were compared for the incidence of intraprocedure SF/NR.</p><p><strong>Results: </strong>A total of 765 patients with high thrombus burden undergoing primary PCI were included in this study. The mean age was 55.75 ± 11.54 years, and 78.6% (601) were males. Predilation ballooning was conducted in 346 (45.2%) patients. The incidence of intraprocedure SF/NR was significantly higher (41.3% vs. 27.4%; <i>p</i> < 0.001) in patients with predilation ballooning than in those without preballooning, respectively. The incidence of intraprocedure SF/NR also remained significantly higher for the predilation ballooning cohort with an incidence rate of 41.3% as against 30.1% (<i>p</i>=0.002) for the propensity-matched cohort of patients without predilation ballooning with a relative risk of 1.64 (95% CI: 1.20 to 2.24). Moreover, the in-hospital mortality rate remained higher but insignificant, among patients with and without predilation ballooning (8.1% vs. 4.9%; <i>p</i>=0.090).</p><p><strong>Conclusion: </strong>In conclusion, predilation ballooning can be associated with an increased risk of incidence of intraprocedure SF/NR during primary PCI in patients with high thrombus burden.</p>\",\"PeriodicalId\":16329,\"journal\":{\"name\":\"Journal of interventional cardiology\",\"volume\":\"2023 \",\"pages\":\"4012361\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839408/pdf/\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of interventional cardiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1155/2023/4012361\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of interventional cardiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/2023/4012361","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 3

摘要

背景:预扩张球囊形成的微血栓碎片导致远端栓塞被认为是慢流/无回流(SF/NR)的可能机制之一。因此,本研究旨在比较高血栓负荷(≥4级)患者在进行和不进行预扩张球囊预备的罪魁祸首病变时,经皮冠状动脉介入治疗(PCI)时术中SF/NR的发生率。方法。这项前瞻性描述性横断面研究纳入了接受首次PCI治疗的高血栓负担(≥4级)患者。对术中SF/NR的发生率进行1:1比例的倾向匹配的有和没有扩张前球囊的患者队列进行比较。结果:本研究共纳入765例接受初级PCI的高血栓负荷患者。平均年龄55.75±11.54岁,男性占78.6%(601例)。346例(45.2%)患者行预扩张球囊术。术中SF/NR的发生率明显更高(41.3% vs. 27.4%;P < 0.001)。术中SF/NR的发生率在预扩张球囊组中也明显较高,为41.3%,而在倾向匹配的无预扩张球囊组中为30.1% (p=0.002),相对危险度为1.64 (95% CI: 1.20至2.24)。此外,住院死亡率仍然较高,但不显著,在有和没有扩张性球囊的患者中(8.1% vs. 4.9%;p = 0.090)。结论:总之,在血栓负担高的患者进行首次PCI时,预扩张球囊可能与术中SF/NR发生率增加有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Predilation Ballooning in High Thrombus Laden STEMIs: An Independent Predictor of Slow Flow/No-Reflow in Patients Undergoing Emergent Percutaneous Coronary Revascularization.

Background: Distal embolization due to microthrombus fragments formed during predilation ballooning is considered one of the possible mechanisms of slow flow/no-reflow (SF/NR). Therefore, this study aimed to compare the incidence of intraprocedure SF/NR during the primary percutaneous coronary intervention (PCI) in patients with high thrombus burden (≥4 grade) with and without predilation ballooning for culprit lesion preparation. Methodology. This prospective descriptive cross-sectional study included patients with a high thrombus burden (≥4 grades) who underwent primary PCI. Propensity-matched cohorts of patients with and without predilation ballooning in a 1 : 1 ratio were compared for the incidence of intraprocedure SF/NR.

Results: A total of 765 patients with high thrombus burden undergoing primary PCI were included in this study. The mean age was 55.75 ± 11.54 years, and 78.6% (601) were males. Predilation ballooning was conducted in 346 (45.2%) patients. The incidence of intraprocedure SF/NR was significantly higher (41.3% vs. 27.4%; p < 0.001) in patients with predilation ballooning than in those without preballooning, respectively. The incidence of intraprocedure SF/NR also remained significantly higher for the predilation ballooning cohort with an incidence rate of 41.3% as against 30.1% (p=0.002) for the propensity-matched cohort of patients without predilation ballooning with a relative risk of 1.64 (95% CI: 1.20 to 2.24). Moreover, the in-hospital mortality rate remained higher but insignificant, among patients with and without predilation ballooning (8.1% vs. 4.9%; p=0.090).

Conclusion: In conclusion, predilation ballooning can be associated with an increased risk of incidence of intraprocedure SF/NR during primary PCI in patients with high thrombus burden.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of interventional cardiology
Journal of interventional cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.80
自引率
0.00%
发文量
81
审稿时长
6-12 weeks
期刊介绍: Journal of Interventional Cardiology is a peer-reviewed, Open Access journal that provides a forum for cardiologists determined to stay current in the diagnosis, investigation, and management of patients with cardiovascular disease and its associated complications. The journal publishes original research articles, review articles, and clinical studies focusing on new procedures and techniques in all major subject areas in the field, including: Acute coronary syndrome Coronary disease Congenital heart diseases Myocardial infarction Peripheral arterial disease Valvular heart disease Cardiac hemodynamics and physiology Haemostasis and thrombosis
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信