美国国立卫生研究院工具箱认知电池在威廉姆斯综合征患者中的可行性。

IF 1.9 4区医学 Q1 EDUCATION, SPECIAL

Ajidd-American Journal on Intellectual and Developmental Disabilities Pub Date : 2022-11-01 DOI:10.1352/1944-7558-127.6.473

Emma E Condy, Lindsey Becker, Cristan Farmer, Aaron J Kaat, Colby Chlebowski, Beth A Kozel, Audrey Thurm

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引用次数: 0

摘要

美国国立卫生研究院工具箱认知电池(NIHTB-CB)是为流行病学和纵向研究而开发的，跨越广泛的年龄跨度。这种工具可能对以智力残疾(ID)为特征的干预试验有用，例如威廉姆斯综合征(WS)。对47名年龄在4 - 50岁的WS患者进行三项NIHTB-CB任务，包括两项执行功能(侧卫，维度变化卡片排序)和一项情景记忆(图片序列记忆)任务，以评估该人群的可行性(即有效给药的比例)。结果表明，NIHTB-CB试验具有良好的可行性。Flanker和DCCS年龄校正分数与年龄呈负相关，并表现出最低效应，表明这些分数可能不适用于量化ID在这些NIHTB-CB测试中的表现。

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NIH Toolbox Cognition Battery Feasibility in Individuals With Williams Syndrome.

The NIH Toolbox Cognition Battery (NIHTB-CB) was developed for epidemiological and longitudinal studies across a wide age span. Such a tool may be useful for intervention trials in conditions characterized by intellectual disability (ID), such as Williams syndrome (WS). Three NIHTB-CB tasks, including two executive functioning (Flanker, Dimensional Change Card Sort) and one episodic memory (Picture Sequence Memory) task, were given to 47 individuals with WS, ages 4 to 50, to evaluate feasibility (i.e., proportion of valid administrations) in this population. Findings indicated that NIHTB-CB tests showed good feasibility. Flanker and DCCS age-corrected scores were negatively correlated with age and showed floor effects, indicating these scores may not be useful for quantifying performance on these NIHTB-CB tests in ID.

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来源期刊

Ajidd-American Journal on Intellectual and Developmental Disabilities Multiple-

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： The American Journal on Intellectual and Developmental Disabilities (Print ISSN: 1944–7515; Online ISSN: 1944–7558) is published by the American Association on Intellectual and Developmental Disabilities. It is a scientifi c, scholarly, and archival multidisciplinary journal for reporting original contributions of the highest quality to knowledge of intellectual disabilities, its causes, treatment, and prevention.