第一次非诱发性癫痫发作后的功能连通性是否与随后的癫痫发作和未来的癫痫诊断不同?

Ga Eun Koo, Ho Tae Jeong, Young Chul Youn, Su-Hyun Han
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引用次数: 0

摘要

背景与目的:目前尚无高度敏感的癫痫生物标志物。最近,在功能连接分析方面取得了令人鼓舞的结果,这可能会在脑电图没有明显异常的情况下提高癫痫的诊断。我们的目的是研究在1年内诊断为癫痫的患者和未诊断为癫痫的患者在首次非诱发性癫痫发作后的功能连通性差异。方法:我们使用iSyncBrain®(iMediSync Inc.,韩国水原)比较了12例1年内被诊断为癫痫(两次或两次以上非诱发性癫痫发作)患者和17例对照组(1年内未被诊断的患者)的定量脑电图功率谱和功能连通性;https://isyncbrain.com/)。在源级分析中,使用标准化的低分辨率脑电磁断层扫描技术评估整个大脑的电流分布,以比较68个感兴趣区域的相对功率值和感兴趣区域之间的连通性(相干性的虚部)。结果:癫痫组定量脑电图显示,与对照组相比,左额叶区、中央区、颞上区和顶叶区α 2频带功率较低,额叶区、中央区、颞叶区、枕叶区和左顶叶区α 2频带功率较高。此外,癫痫患者在α 2和β 2波段的连通性明显低于对照组。结论:第一次非诱发性癫痫发作的患者根据是否有后续癫痫发作和未来癫痫发作表现出不同的脑功能。我们的研究结果提出了潜在的临床能力,诊断癫痫后的第一次非诱发性发作,在没有癫痫样放电间期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Is Functional Connectivity after a First Unprovoked Seizure Different Based on Subsequent Seizures and Future Diagnosis of Epilepsy?

Background and purpose: There are no highly sensitive biomarkers for epilepsy to date. Recently, promising results regarding functional connectivity analysis have been obtained, which may improve epilepsy diagnosis even in the absence of visible abnormality in electroencephalography. We aimed to investigate the differences in functional connectivity after a first unprovoked seizure between patients diagnosed with epilepsy within 1 year due to subsequent seizures and those who were not.

Methods: We compared quantitative electroencephalography power spectra and functional connectivity between 12 patients who were diagnosed with epilepsy (two or more unprovoked seizures) within 1 year and 17 controls (those not diagnosed within 1 year) using iSyncBrain® (iMediSync Inc., Suwon, Korea; https://isyncbrain.com/). In the source-level analysis, the current distribution across the brain was assessed using the standardized low-resolution brain electromagnetic tomography technique, to compare relative power values in 68 regions of interest and connectivity (the imaginary part of coherency) between regions of interest.

Results: In the epilepsy group, quantitative electroencephalography showed lower alpha2 band power in left frontal, central, superior temporal, and parietal regions and higher beta2 power in both frontal, central, temporal, occipital, and left parietal regions compared with the control group. Additionally, epilepsy patients had significantly lower connectivity in alpha2 and beta2 bands than the controls.

Conclusions: Patients experiencing their first unprovoked seizure presented different brain function according to whether they have subsequent seizures and future epilepsy. Our results propose the potential clinical ability to diagnose epilepsy after the first unprovoked seizure in the absence of interictal epileptiform discharges.

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