玻璃离聚体水泥的遗传毒性评价:系统综述。

IF 5.7 2区医学 Q1 TOXICOLOGY

Critical Reviews in Toxicology Pub Date : 2022-05-01 DOI:10.1080/10408444.2022.2101914

Ingra Tais Malacarne, Wilton Mitsunari Takeshita, Daniel Vitor de Souza, Marcia Regina Nagaoka, Odair Aguiar, Ana Claudia Muniz Renno, Daniel Araki Ribeiro

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引用次数: 3

摘要

通过系统综述，评价玻璃离聚体水泥的遗传毒性。对问题、干预、控制和结果(PICOS)策略进行了系统回顾，旨在回答以下问题:“玻璃离聚体水泥能否在体外和体内诱导遗传损伤?”系统检索了以下电子数据库:PubMed(包括MedLine)、Web of Science和Scopus。采用有效公共卫生实践项目(EPHPP)评估纳入研究的质量。在作者对所有文章进行综述后，共有13篇文章符合系统综述的全部纳入标准。根据EPHPP的参数，8篇文章被分类为强或中等质量。其他的研究(五项研究)是弱的。综上所述，我们的研究结果表明，六项研究报告了改性玻璃离聚体水泥的遗传毒性测试，两项研究得出遗传毒性的影响是时间依赖性的结论。

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Assessment of genotoxicity of glass ionomer cements: a systematic review.

To evaluate, through a systematic review, the assessment of genotoxicity of glass ionomer cements in vitro and in vivo. A systematic review was performed with the problem, intervention, control, and outcomes (PICOS) strategy, aiming to answer the following question: "Can glass ionomer cements induce genetic damage in vitro and in vivo?" A systematic search was performed in the following electronic databases: PubMed (including MedLine), Web of Science, and Scopus. The quality of included studies was assessed using the Effective Public Health Practice Project (EPHPP). After the authors performed the review of all articles, a total of 13 manuscripts met all the inclusion criteria in the systematic review. Following the parameters of the EPHPP, eight articles were classified as strong or moderate quality. The other ones (five studies) were weak. Taken together our results demonstrated that, six studies reported genotoxicity of the modified glass ionomer cements tested and two studies concluded that the effect of genotoxicity was time dependent.

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来源期刊

Critical Reviews in Toxicology 医学-毒理学

CiteScore

9.50

自引率

1.70%

发文量

期刊介绍： Critical Reviews in Toxicology provides up-to-date, objective analyses of topics related to the mechanisms of action, responses, and assessment of health risks due to toxicant exposure. The journal publishes critical, comprehensive reviews of research findings in toxicology and the application of toxicological information in assessing human health hazards and risks. Toxicants of concern include commodity and specialty chemicals such as formaldehyde, acrylonitrile, and pesticides; pharmaceutical agents of all types; consumer products such as macronutrients and food additives; environmental agents such as ambient ozone; and occupational exposures such as asbestos and benzene.