SPARC/ON在人骨肉瘤中的作用。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Consolato M Sergi
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引用次数: 0

摘要

人骨肉瘤是一种发生在关节-骨骼系统的恶性肿瘤。它被认为是最常见的恶性肿瘤,其次是尤文氏肉瘤或原始神经外胚层肿瘤。预后是令人担忧的,并不能保留使用经典化疗药物。这种恶性肿瘤常伴有高复发和转移率。化疗经常因为多药耐药的发生而失败,尽管达到化疗耐药的机制仍然很有趣,并且包含不明确的途径。在一些恶性肿瘤中,分泌的酸性且富含半胱氨酸(SPARC)或骨连接蛋白(ON) (SPARC/ON)与预后不良有关。在这篇综述中,我们将重点介绍SPARC/ON在人骨肉瘤中的作用。细胞外囊泡是细胞间通讯的基础。我们建议针对SPARC/ON的液体活检可能是监测这种恶性骨肿瘤患者的关键。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of SPARC/ON in human osteosarcoma.

The human osteosarcoma is a malignant tumor of the arthro-skeletal system. It has been recognized that it is the most common malignancy followed by the Ewing sarcoma or primitive neuroectodermal tumor. The prognosis is worrisome and is not preserved by the use of classical chemotherapy drugs. High rates of recurrence and metastases often accompany this malignant tumor. Chemotherapy often fails because of the onset of multidrug resistance, even though the mechanism to reach chemotherapy resistance is still intriguing and contains unclear pathways. The secreted protein acidic and rich in cysteine (SPARC) or osteonectin (ON) (SPARC/ON) has been associated with poor prognosis in several malignant neoplasms. In this mini-review, we are going to highlight the role of SPARC/ON in human osteosarcoma. Extracellular vesicles are fundamental in cell-to-cell communication. We suggest that a liquid biopsy targeting SPARC/ON may be critical to implement in the surveillance of patients with this malignant bony neoplasm.

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来源期刊
Advances in protein chemistry and structural biology
Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
7.40
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
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