三种计算机半自动化分析食蟹猴长期遥测心电图室性心律失常的方法的性能和可行性

IF 1.3 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Jörg Eiringhaus , Anna-Lena de Vries , Stephan Hohmann , Dietmar Böthig , Johanna Müller-Leisse , Henrike A.K. Hillmann , Andreas Martens , Robert Zweigerdt , Annette Schrod , Ulrich Martin , David Duncker , Ina Gruh , Christian Veltmann
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引用次数: 0

摘要

在动物模型中,基于计算机的长期心电图(ECG)监测分析是一个成本高且耗时的过程,因为通常要进行人工监测以确保心律失常检测的准确性。在这里,我们研究了三种ECG间隔分析方法的性能和可行性:A)基于属性的,B)基于属性和模式识别的,C)结合额外的手动搏动分析(金标准)的方法,关于随后检测室性心律失常(VA)和时间消耗。对5只雄性食蟹猴(共1000 h,每只2 × 100 h)的心电图原始数据进行心电图分析。与金标准相比,A和B两种方法都高估了心律失常的总数(+8.92%对+6.47%)。对于检测到的室性心律事件数(加速室性心律[AIVR],室性心动过速[VT])的正确分类,方法B比方法A显示出更高的准确性。重要的是,当使用方法B时,准确地描述了室性心律负担(时间的百分比)(- 1.13%),而方法A导致室性心律失常的相关感知不足(- 11.76%)。值得注意的是,与金标准相比,方法A和B可以用更少的工作时间(- 95%和- 91%的工作时间)来执行。总之,我们表明基于属性和模式识别分析(方法B)的组合可以在不使用人工监督的情况下以可接受的精度再现VA负担。由于这种方法允许以明显节省时间的方式进行分析,因此它代表了对大型临床前ECG数据集进行成本和时间效率分析的有价值的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Performance and feasibility of three different approaches for computer based semi-automated analysis of ventricular arrhythmias in telemetric long-term ECG in cynomolgus monkeys

Computer-based analysis of long-term electrocardiogram (ECG) monitoring in animal models represents a cost and time-consuming process as manual supervision is often performed to ensure accuracy in arrhythmia detection. Here, we investigate the performance and feasibility of three ECG interval analysis approaches A) attribute-based, B) attribute- and pattern recognition-based and C) combined approach with additional manual beat-to-beat analysis (gold standard) with regard to subsequent detection of ventricular arrhythmias (VA) and time consumption. ECG analysis was performed on ECG raw data of 5 male cynomolgus monkeys (1000 h total, 2 × 100 h per animal). Both approaches A and B overestimated the total number of arrhythmias compared to gold standard (+8.92% vs. +6.47%). With regard to correct classification of detected VA event numbers (accelerated idioventricular rhythms [AIVR], ventricular tachycardia [VT]) approach B revealed higher accuracy compared to approach A. Importantly, VA burden (% of time) was precisely depicted when using approach B (−1.13%), whereas approach A resulted in relevant undersensing of ventricular arrhythmias (−11.76%). Of note, approach A and B could be performed with significant less working time (−95% and − 91% working time) compared to gold standard. In sum, we show that a combination of attribute-based and pattern recognition analysis (approach B) can reproduce VA burden with acceptable accuracy without using manual supervision. Since this approach allowed analyses to be performed with distinct time saving it represents a valuable approach for cost and time efficient analysis of large preclinical ECG datasets.

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来源期刊
Journal of pharmacological and toxicological methods
Journal of pharmacological and toxicological methods PHARMACOLOGY & PHARMACY-TOXICOLOGY
CiteScore
3.60
自引率
10.50%
发文量
56
审稿时长
26 days
期刊介绍: Journal of Pharmacological and Toxicological Methods publishes original articles on current methods of investigation used in pharmacology and toxicology. Pharmacology and toxicology are defined in the broadest sense, referring to actions of drugs and chemicals on all living systems. With its international editorial board and noted contributors, Journal of Pharmacological and Toxicological Methods is the leading journal devoted exclusively to experimental procedures used by pharmacologists and toxicologists.
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