为什么某些癌症细胞会改变功能并融合？

IF 2.9 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biological Chemistry Pub Date : 2023-05-30 Print Date: 2023-09-26 DOI:10.1515/hsz-2023-0162

Thomas Dittmar, Mareike Sieler, Ralf Hass

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引用次数: 1

摘要

癌症细胞融合是一个罕见的事件。然而，在杂交后选择过程（PHSP）后存活的癌症杂交细胞可以通过表现出增殖优势和/或癌症干样特性的表达而过度生长其他癌症细胞。在癌症细胞例如与间充质间质/干样细胞（MSC）的异融合过程中添加新的肿瘤特性有助于通过获得新的/改变的功能来增强肿瘤的可塑性。这为肿瘤的发展和转移行为提供了新的途径。因此，本综述文章还将探讨癌症细胞融合是一个普遍的、可能进化保守的程序，还是一个随机的过程？

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Why do certain cancer cells alter functionality and fuse?

Cancer cell fusion represents a rare event. However, the surviving cancer hybrid cells after a post-hybrid selection process (PHSP) can overgrow other cancer cells by exhibiting a proliferation advantage and/or expression of cancer stem-like properties. Addition of new tumor properties during hetero-fusion of cancer cells e.g. with mesenchymal stroma-/stem-like cells (MSC) contribute to enhanced tumor plasticity via acquisition of new/altered functionalities. This provides new avenues for tumor development and metastatic behavior. Consequently, the present review article will also address the question as to whether cancer cell fusion represents a general and possibly evolutionary-conserved program or rather a random process?

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来源期刊

Biological Chemistry 生物-生化与分子生物学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Biological Chemistry keeps you up-to-date with all new developments in the molecular life sciences. In addition to original research reports, authoritative reviews written by leading researchers in the field keep you informed about the latest advances in the molecular life sciences. Rapid, yet rigorous reviewing ensures fast access to recent research results of exceptional significance in the biological sciences. Papers are published in a "Just Accepted" format within approx.72 hours of acceptance.