男性合成代谢雄激素类固醇滥用与睾丸功能的关系最近的见解

IF 4 3区医学 Q1 PHARMACOLOGY & PHARMACY

Current Opinion in Pharmacology Pub Date : 2022-12-01 DOI:10.1016/j.coph.2022.102318

Willem de Ronde , Diederik L. Smit

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引用次数: 2

摘要

年轻男性非法使用雄激素的情况并不少见。大多数使用者在其一生中服用多个疗程的雄激素，导致高累积暴露。一个不可分割的副作用是抑制性腺功能。虽然这通常会恢复，但恢复可能需要很长时间，并且不是没有症状。这篇综述的重点是最近的研究，这些研究大大增加了我们对雄激素滥用期间和之后睾丸功能的破坏和恢复的认识。对于(潜在)用户的指导和治疗，深入了解这一点是必不可少的。

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Anabolic–androgenic steroid abuse and testicular function in men; recent insights

The use of illegal androgens by young men is not uncommon. The majority of users take multiple courses of androgens during their lifetime, leading to a high cumulative exposure. An inseparable side effect is suppression of gonadal function. Although this usually recovers, recovery can take a long time and is not without symptoms.

This review focusses on recent studies that have greatly increased our knowledge of the disruption and recovery of testicular function during and after androgen abuse. For the guidance and treatment of (potential) users, in-depth knowledge of this is indispensable.

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来源期刊

Current Opinion in Pharmacology 医学-药学

CiteScore

8.80

自引率

2.50%

发文量

131

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.