Bcl11b和Atoh8协调细胞重编程和转化的可塑性。

IF 1.2 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Cellular reprogramming Pub Date : 2022-12-01 Epub Date: 2022-11-21 DOI:10.1089/cell.2022.0128

Mo-Fan Huang, Rachel Shoemaker, Dung-Fang Lee

引用次数: 1

摘要

Huyghe等通过在单细胞分辨率上解剖和比较重编程和转化细胞的转录轨迹和表观基因组特征，发现Bcl11b和Atoh8是多能重编程和致癌转化过程中控制细胞可塑性的两个关键转录因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Bcl11b and Atoh8 Coordinate Cellular Plasticity for Reprogramming and Transformation.

By dissecting and comparing the transcriptional trajectories and epigenomic traits of reprogramming and transforming cells at the single-cell resolution, Huyghe et al discovered Bcl11b and Atoh8, two key transcription factors controlling cell plasticity during pluripotent reprogramming and oncogenic transformation.

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来源期刊

Cellular reprogramming CELL & TISSUE ENGINEERING-BIOTECHNOLOGY & APPLIED MICROBIOLOGY

CiteScore

2.50

自引率

6.20%

发文量

审稿时长

3 months

期刊介绍： Cellular Reprogramming is the premier journal dedicated to providing new insights on the etiology, development, and potential treatment of various diseases through reprogramming cellular mechanisms. The Journal delivers information on cutting-edge techniques and the latest high-quality research and discoveries that are transforming biomedical research. Cellular Reprogramming coverage includes: Somatic cell nuclear transfer and reprogramming in early embryos Embryonic stem cells Nuclear transfer stem cells (stem cells derived from nuclear transfer embryos) Generation of induced pluripotent stem (iPS) cells and/or potential for cell-based therapies Epigenetics Adult stem cells and pluripotency.