沿着大麻素和内源性大麻素化学和药理学途径的愉快旅行。

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Raphael Mechoulam
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引用次数: 5

摘要

第二次世界大战期间,我在欧洲度过了一个痛苦的童年,之后我发现在以色列进行科学研究是一种超出我预期的快乐。在过去的65年里,我一直在研究天然产物的化学和药理学。在过去的几十年里,我的大部分研究都集中在植物大麻素上,内源性大麻素花生四烯醇乙醇酰胺(anandamide)和2-花生四烯醇甘油,以及内源性类似花生四烯醇的化合物,所有这些都参与了广泛的生理反应。两种植物大麻素Δ9-tetrahydrocannabinol和大麻二酚是被批准的药物。然而,内源性大麻素和大麻酰胺样成分尚未在人体中得到很好的研究。对我来说,思想自由——基于自己的科学兴趣进行研究的能力——是我工作生涯中最令人满意的部分。回顾我长达91年的漫长人生,我的结论是,我很幸运,无论是个人还是科学上都非常幸运。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Delightful Trip Along the Pathway of Cannabinoid and Endocannabinoid Chemistry and Pharmacology.

After a traumatic childhood in Europe during the Second World War, I found that scientific research in Israel was a pleasure beyond my expectations. Over the last 65 year, I have worked on the chemistry and pharmacology of natural products. During the last few decades, most of my research has been on plant cannabinoids, the endogenous cannabinoids arachidonoyl ethanolamide (anandamide) and 2-arachidonoyl glycerol, and endogenous anandamide-like compounds, all of which are involved in a wide spectrum of physiological reactions. Two plant cannabinoids, Δ9-tetrahydrocannabinol and cannabidiol, are approved drugs. However, the endogenous cannabinoids and the anandamide-like constituents have not yet been well investigated in humans. For me, intellectual freedom-the ability to do research based on my own scientific interests-has been the most satisfying part of my working life. Looking back over the 91 years of my long life, I conclude that I have been lucky, very lucky, both personally and scientifically.

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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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