dsDNA自身抗体在系统性红斑狼疮患者诊断、分型及随访中的应用

IF 4.7 Q2 IMMUNOLOGY
Jan Damoiseaux, Joyce van Beers
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引用次数: 2

摘要

自身抗体,特别是抗dsDNA抗体,越来越多地用于SLE患者的诊断、分类和随访。由于自身抗体检测的标准化是一个重大挑战,因此应更多地关注统一举措和在分类标准中更好地定义所需的检测特征。为了诊断和随访,需要进行单独的多中心研究,以确定用于这两个目的的不同免疫测定的测试特征。最后,此类研究不应考虑将SLE评估为单一疾病,而应考虑将其评估为具有不同亚型的疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Autoantibodies to dsDNA in the diagnosis, classification and follow-up of patients with systemic lupus erythematosus

Autoantibodies to dsDNA in the diagnosis, classification and follow-up of patients with systemic lupus erythematosus

Autoantibodies to dsDNA in the diagnosis, classification and follow-up of patients with systemic lupus erythematosus

Autoantibodies, in particular anti-dsDNA antibodies, are increasingly used for diagnosis, classification and follow-up of patients with SLE. Since standardization of autoantibody assays is a major challenge, more attention should be paid to harmonization initiatives and better definition of required test characteristics in classification criteria. For diagnosis and follow-up separate multi-center studies are required to establish test characteristics of distinct immuno-assays for both purposes. Finally, such studies should consider not to evaluate SLE as a single disease, but as a disease with distinct subtypes.

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来源期刊
Journal of Translational Autoimmunity
Journal of Translational Autoimmunity Medicine-Immunology and Allergy
CiteScore
7.80
自引率
2.60%
发文量
33
审稿时长
55 days
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