利福平对产前酒精暴露大鼠前脑皮质toll样受体系统基因表达的影响。

Q3 Biochemistry, Genetics and Molecular Biology

Biomeditsinskaya khimiya Pub Date : 2023-09-01 DOI:10.18097/PBMC20236904228

M I Airapetov, S O Eresko, P D Ignatova, D A Skabelkin, A A Mikhailova, D A Ganshina, A A Lebedev, E R Bychkov, P D Shabanov

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引用次数: 0

摘要

乙醇引起toll样受体(TLR)系统的长期变化，促进神经炎症通路的激活。怀孕期间饮酒会导致胎儿神经炎症;这可能导致胎儿酒精谱系障碍(FASD)症状的发展。我们的研究表明，产前酒精暴露(PAE)诱导大鼠前脑皮层TLR系统基因(Tlr3, Tlr4, Ticam, Hmgb1，细胞因子基因)的长期变化。利福平(Rif)可以降低神经系统各种病理条件下促炎介质的水平，使所研究的TLR系统基因的表达水平正常化。这表明Rif可以预防由TLR系统失调引起的大鼠幼鼠前脑皮质持续神经炎症事件的发生。

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The effect of rifampicin on expression of the toll-like receptor system genes in the forebrain cortex of rats prenatally exposed to alcohol.

Ethanol causes long-term changes in the toll-like receptor (TLR) system, promoting activation of neuroinflammation pathways. Alcohol use during pregnancy causes neuroinflammatory processes in the fetus; this can lead to the development of symptoms of fetal alcohol spectrum disorder (FASD). Our study has shown that prenatal alcohol exposure (PAE) induced long-term changes in the TLR system genes (Tlr3, Tlr4, Ticam, Hmgb1, cytokine genes) in the forebrain cortex of rat pups. Administration of rifampicin (Rif), which can reduce the level of pro-inflammatory mediators in various pathological conditions of the nervous system, normalized the altered expression level of the studied TLR system genes. This suggests that Rif can prevent the development of persistent neuroinflammatory events in the forebrain cortex of rat pups caused by dysregulation in the TLR system.

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来源期刊

Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).