猴痘的致病观点和治疗模式:中心教条

Q3 Pharmacology, Toxicology and Pharmaceutics
Shivang Dhoundiyal, Md Aftab Alam, Awaneet Kaur, Sandesh Varshney
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引用次数: 0

摘要

猴痘病毒(MPXV)属于正痘病毒属,是引起猴痘这种人畜共患疾病的罪魁祸首。这种病毒最初是在 1958 年丹麦动物园爆发的一次疫情中被发现的,此后又在全球范围内被发现感染各种哺乳动物。虽然非洲松鼠和其他啮齿类动物被认为是主要宿主,但事实证明确定自然宿主具有挑战性。虽然可以在实验室环境中使用不同的动物模型对 MPXV 进行研究,但对其自然传播途径的了解仍然十分复杂,而且取决于不同的物种。最近的事态发展提高了全球对猴痘的健康关注,导致该病毒于 2022 年 7 月 23 日被指定为国际关注的全球紧急卫生事件。加强监测和病例检测对于应对这种重新出现的疾病不可预测的流行病学至关重要。由于人口增长和经济发展,人类感染猴痘病毒的频率越来越低。猴痘与天花类似,未来有可能通过疫苗、适当的治疗和个人防护设备得到控制和根除。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Burdening Perspectives and Treatment Modalities of Monkeypox: A Central Dogma.

The monkeypox virus (MPXV), belonging to the genus Orthopoxvirus, is responsible for causing the zoonotic illness known as Monkeypox. The virus was initially identified during an outbreak at a Danish Zoo in 1958 and has since been found to infect various mammal species worldwide. While African squirrels and other rodents are believed to be the primary hosts, determining the natural host has proven challenging. While MPXV can be studied using different animal models in laboratory settings, understanding its natural transmission routes remains complex and species-dependent. Recent developments have elevated the global health concern surrounding Monkeypox, leading to its designation as a Global Health Emergency of International Concern on 23 July 2022. Enhancing surveillance and case detection is crucial in navigating the unpredictable epidemiology of this re-emerging disease. Human infections with the monkeypox virus are becoming less frequent due to population growth and economic improvements. Monkeypox, similar to smallpox, can potentially be controlled and eradicated in the future through vaccines, appropriate treatment, and personal protective equipment.

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来源期刊
Infectious disorders drug targets
Infectious disorders drug targets Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
3.10
自引率
0.00%
发文量
123
期刊介绍: Infectious Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in infectious disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in infectious disorders. As the discovery, identification, characterization and validation of novel human drug targets for anti-infective drug discovery continues to grow, this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.
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